{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:01:29Z","timestamp":1790694089422,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T00:00:00Z","timestamp":1485216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006034","name":"University of Southern California","doi-asserted-by":"publisher","award":["HHSN261201000034C"],"award-info":[{"award-number":["HHSN261201000034C"]}],"id":[{"id":"10.13039\/100006034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001808","name":"Public Health Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001808","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Patient\u2010reported toxicities help to appraise the breast cancer treatment experience. Yet extant data come from clinical trials and health care claims, which may be biased. Using patient surveys, the authors sought to quantify the frequency, severity, and burden of treatment\u2010associated toxicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Between 2013 and 2014, the iCanCare study surveyed a population\u2010based sample of women residing in Los Angeles County and Georgia with early\u2010stage, invasive breast cancer. The authors assessed the frequency and severity of toxicities; correlated toxicity severity with unscheduled health care use (clinic visits, emergency department visits\/hospitalizations) and physical health; and examined patient, tumor, and treatment factors associated with reporting increased toxicity severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The overall survey response rate was 71%. From the analyzed cohort of 1945 women, 866 (45%) reported at least 1 toxicity that was severe\/very severe, 9% reported unscheduled clinic visits for toxicity management, and 5% visited an emergency department or hospital. Factors associated with reporting higher toxicity severity included receipt of chemotherapy (odds ratio [OR], 2.2; 95% confidence interval [95% CI], 2.0\u20102.5), receipt of both chemotherapy and radiotherapy (OR, 1.3; 95% CI, 1.0\u20101.7), and Latina ethnicity (OR vs whites: 1.3; 95% CI, 1.1\u20101.5). A nonsignificant increase in at least 1 severe\/very severe toxicity report was observed for bilateral mastectomy recipients (OR, 1.2; 95% CI, 1.0\u20101.4).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Women with early\u2010stage invasive breast cancer report substantial treatment\u2010associated toxicities and related burden. Clinicians should collect toxicity data routinely and offer early intervention. Toxicity differences observed by treatment modality may inform decision making. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:1925\u20131934<\/jats:bold>. \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30547","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T10:07:56Z","timestamp":1485252476000},"page":"1925-1934","source":"Crossref","is-referenced-by-count":80,"title":["Treatment\u2010associated toxicities reported by patients with early\u2010stage invasive breast cancer"],"prefix":"10.1002","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2281-2056","authenticated-orcid":false,"given":"Christopher R.","family":"Friese","sequence":"first","affiliation":[{"name":"Department of Systems Populations, and Leadership, School of Nursing, University of Michigan Ann Arbor Michigan"},{"name":"Institute for Healthcare Policy and Innovation University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan M.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Systems Populations, and Leadership, School of Nursing, University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy K.","family":"Janz","sequence":"additional","affiliation":[{"name":"Department of Health Behavior and Health Education School of Public Health, University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reshma","family":"Jagsi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Michigan School of Medicine Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Morrow","sequence":"additional","affiliation":[{"name":"Breast Surgical Service Memorial Sloan Kettering Cancer Center New York New 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