{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:29:15Z","timestamp":1790360955308,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Oral Cancer Foundation"},{"name":"Ohio State University Comprehensive Cancer Center"},{"name":"Miren Taberna's fellowship"},{"name":"Rio Hortega-Spanish Society of Medical Oncology grant (Carlos III Health Institute) and the University of Barcelona"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Sexual behavior and oral human papillomavirus (HPV) infection are risk factors for oral squamous cell carcinoma (OSCC). The effects of OSCC diagnosis and treatment on subsequent relationship stress and sexual behavior are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Incident cases of HPV\u2010positive or HPV\u2010negative OSCC in patients who had a partnered relationship and partners of patients with oropharyngeal cancer were eligible for a study in which surveys were administered at diagnosis and at the 6\u2010month follow\u2010up time point to assess relationship distress, HPV transmission and concerns about health consequences, and sexual behavior. The frequency distributions of responses, stratified by tumor HPV status, were compared at baseline and follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In total, 262 patients with OSCC and 81 partners were enrolled. Among the patients, 142 (54.2%) had HPV\u2010positive OSCC, and 120 (45.8%) had HPV\u2010negative OSCC. Relationship distress was infrequently reported, and 69% of patients felt that their relationship had strengthened since the cancer diagnosis. Both HPV\u2010positive patients (25%) and their partners (14%) reported feelings of guilt or responsibility for the diagnosis of an HPV\u2010caused cancer. Concern over sexual, but not nonsexual, HPV transmission to partners was reported by 50%. Significant declines in the frequency of vaginal and oral sexual behaviors were reported at follow\u2010up, regardless of tumor HPV status. From baseline to 6 months, significant increases in abstinence from vaginal sex (from 10% to 34%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) and oral sex (from 25% to 80%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Diagnosis and treatment of OSCC are associated with significant declines in the frequency of vaginal and oral sex, regardless of tumor HPV status. Sexual behavior is an important quality\u2010of\u2010life outcome to assess within clinical trials. [See related editorial on pages 000\u2010000, this issue.] <jats:bold><jats:italic>Cancer<\/jats:italic> 2017<\/jats:bold>. \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:1156\u20131165.<\/jats:bold> \u00a9 <jats:italic>2016 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30564","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T10:16:46Z","timestamp":1487067406000},"page":"1156-1165","source":"Crossref","is-referenced-by-count":49,"title":["Significant changes in sexual behavior after a diagnosis of human papillomavirus\u2010positive and human papillomavirus\u2010negative oral cancer"],"prefix":"10.1002","volume":"123","author":[{"given":"Miren","family":"Taberna","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat Barcelona Spain"},{"name":"Cancer Epidemiology Research Program Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat Barcelona Spain"},{"name":"Department of Medicine University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.","family":"Inglehart","sequence":"additional","affiliation":[{"name":"Medical Scientist Training Program The Ohio State University College of Medicine Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K. 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