{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:34:34Z","timestamp":1761863674633,"version":"build-2065373602"},"reference-count":47,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Lynn Sage Foundation"},{"name":"Dolores Knes Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Postdiagnosis weight gain in patients with breast cancer has been associated with increased cancer recurrence and mortality. This study was designed to identify risk factors for weight gain and create a predictive model to identify a high\u2010risk population for targeted interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The weight of 393 patients with breast cancer from the Northwestern Robert H. Lurie Cancer Center was measured over a 2\u2010year period from diagnosis, with body mass index (BMI) change over 18 months as the primary endpoint. Demographics, clinical factors, treatment methods, as well as tumor characteristics were also recorded; and a lifestyle questionnaire was conducted. Blood samples were genotyped for 16 single nucleotide polymorphisms in <jats:italic>FTO<\/jats:italic>, adiponectin pathway genes (<jats:italic>ADIPOQ<\/jats:italic>, <jats:italic>ADIPOR1<\/jats:italic>), and <jats:italic>FNDC5<\/jats:italic>. Serum leptin, adiponectin, and irisin levels also were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Mean \u00b1 standard deviation 18\u2010month BMI changes were 0.68 \u00b1 1.42, 0.98 \u00b1 1.62, 0.79 \u00b1 1.74, and \u22120.44 \u00b1 1.58 kg\/m<jats:sup>2<\/jats:sup> for patients ages &lt;40, 40 to 49, 50 to 59, and \u226560 years, respectively. The optimal multivariable model for 18\u2010month BMI change contained the predictors age, height, and endocrine therapy, but only age was statistically significant, with a 0.04 kg\/m<jats:sup>2<\/jats:sup> increase in 18\u2010month BMI change per younger year of age. Single nucleotide polymorphisms in <jats:italic>ADIPOR1<\/jats:italic>, <jats:italic>FTO<\/jats:italic>, and <jats:italic>FNDC5<\/jats:italic> were associated with 18\u2010month BMI change, and the first 2 remained significant after adjusting for the optimal clinical model (all <jats:italic>P<\/jats:italic> &lt; .05).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Women age 60 years and younger at the time of breast cancer diagnosis who have an obesity genetic risk model are at increased risk for weight gain after treatment and should be targeted for weight\u2010maintenance interventions. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:2413\u201321.<\/jats:bold> \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30628","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T10:17:52Z","timestamp":1487067472000},"page":"2413-2421","source":"Crossref","is-referenced-by-count":14,"title":["A prospective evaluation of clinical and genetic predictors of weight changes in breast cancer survivors"],"prefix":"10.1002","volume":"123","author":[{"given":"Maureen","family":"Sadim","sequence":"first","affiliation":[{"name":"Robert H. 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