{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:08:44Z","timestamp":1792372124023,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,7,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) is the only treatment with a curative potential for myelodysplastic syndrome (MDS) patients. Allo\u2010HSCT has substantial risks, particularly in the elderly, and its role for older MDS patients has yet to be defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We analyzed 88 MDS patients aged\u2009\u2265\u200960 years with allo\u2010HSCT after reduced intensity conditioning regimens over the last decade. The study cohort had high risk features; 47 of 88 (53.4%) patients were\u2009&gt;\u200965 years of age, 24 (27%) patients had cytogenetic abnormalities consistent with monosomal karyotype (MKpos), 33 (38%) patients had histological subtype of RAEB\u20101 and RAEB\u20102 at diagnosis, and 45 (51%) patients had a hematopoietic cell transplantation\u2013comorbidity index (HCT\u2010CI) of\u2009\u2265\u20093.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The 3\u2010year incidence of progression, transplant\u2010related mortality (TRM), and overall survival (OS) were 26% (95% confidence interval [CI], 18%\u201037%), 35% (95% CI, 26%\u201047%), and 41% (95% CI, 30%\u201052%), respectively. MKpos was the only prognostic factor that increased the risk of disease progression compared with good\u2010risk cytogenetics (hazard ratio [HR]\u2009=\u20099.5, <jats:italic>P<\/jats:italic>\u2009=\u2009.003) as well as MKneg (HR\u2009=\u20093.3, <jats:italic>P<\/jats:italic>\u2009=\u2009.01). For TRM, HCT\u2010CI\u2009\u2265\u20093, but not age &gt;65 years, was associated with worse outcomes (HR\u2009=\u20093.1, <jats:italic>P<\/jats:italic>\u2009=\u2009.007). Cytogenetics and HCT\u2010CI enabled us to identify prognostic groups for OS. MKpos patients had the worst 3\u2010year OS (17%), whereas patients with good\u2010risk cytogenetics and HCT\u2010CI\u2009&lt;\u20093 had the best OS (92%).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Our results confirm that allo\u2010HSCT can provide long\u2010term survival in older MDS patients. Cytogenetics and HCT\u2010CI identify prognostic risk groups and guide selection of older MDS patients who are candidates for allo\u2010HSCT. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:2661\u201070<\/jats:bold>. \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30632","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T06:02:44Z","timestamp":1490162564000},"page":"2661-2670","source":"Crossref","is-referenced-by-count":13,"title":["Cytogenetics and comorbidity predict outcomes in older myelodysplastic syndrome patients after allogeneic stem cell transplantation using reduced intensity conditioning"],"prefix":"10.1002","volume":"123","author":[{"given":"Orhan Kemal","family":"Yucel","sequence":"first","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston 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The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qaiser","family":"Bashir","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan O.","family":"Ciurea","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday","family":"Popat","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isa","family":"Khouri","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Marin","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy","family":"Rezvani","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partow","family":"Kebriaei","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Shpall","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Champlin","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1264-5968","authenticated-orcid":false,"given":"Bet\u00fcl","family":"Oran","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston 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