{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:42:59Z","timestamp":1790030579131,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA115873"],"award-info":[{"award-number":["R01 CA115873"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2015\u201002625"],"award-info":[{"award-number":["2015\u201002625"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2015\u201006268"],"award-info":[{"award-number":["2015\u201006268"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2013GXNSFGA 019002"],"award-info":[{"award-number":["2013GXNSFGA 019002"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,7,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>To the authors' knowledge, no studies to date have explored familial risks of nasopharyngeal carcinoma (NPC) in detail and quantified its lifetime risk in high\u2010incidence populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors conducted a population\u2010based case\u2010control study of 2499 NPC cases and 2576 controls randomly selected in southern China from 2010 through 2014. Unconditional logistic regression was used to estimate multivariable\u2010adjusted odds ratios (ORs) with 95% confidence intervals (95% CIs) associated with a family history of NPC. In addition, the authors compiled a reconstructed cohort comprising 40,781 first\u2010degree relatives of cases and controls to calculate the lifetime cumulative risk of NPC.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Individuals with a first\u2010degree family history of NPC were found to be at a &gt;4\u2010fold risk of NPC (OR, 4.6; 95% CI, 3.5\u20106.1) compared with those without such a history, but had no excess risk of other malignancies. The excess risk was higher for a maternal than a paternal history and was slightly stronger for a sibling compared with a parental history, and for a sororal than a fraternal history. Among relatives of cases, the cumulative risk of NPC up to age 74 years was 3.7% (95% CI, 3.3%\u20104.2%), whereas that among relatives of controls was 0.9% (95% CI, 0.7%\u20101.2%). Cumulative risk was higher in siblings than in parents among relatives of cases, whereas no such difference was noted among relatives of controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Individuals with a family history of NPC have a substantially higher risk of NPC. These relative and cumulative risk estimates can guide the development of strategies for early detection and clinical consultation in populations with a high incidence of NPC. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:2716\u201025<\/jats:bold>. \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30643","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T16:12:45Z","timestamp":1488211965000},"page":"2716-2725","source":"Crossref","is-referenced-by-count":69,"title":["Quantification of familial risk of nasopharyngeal carcinoma in a high\u2010incidence area"],"prefix":"10.1002","volume":"123","author":[{"given":"Zhiwei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen 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Molecular Mechanism Wuzhou Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"},{"name":"Key Laboratory of High\u2010Incidence Tumor Prevention and Treatment Guangxi Medical University, Ministry of Education Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guomin","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Infectious Diseases Prevention and Control Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2010Hong","family":"Huang","sequence":"additional","affiliation":[{"name":"Sihui Cancer Institute Sihui Guangdong 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