{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:14:44Z","timestamp":1782184484632,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T00:00:00Z","timestamp":1488499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["121297\u2010PF\u201011\u2010169\u201001\u2010PCSM"],"award-info":[{"award-number":["121297\u2010PF\u201011\u2010169\u201001\u2010PCSM"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001168","name":"Hille Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001168","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["1K01AT008485\u201001"],"award-info":[{"award-number":["1K01AT008485\u201001"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Chemotherapy\u2010induced peripheral neuropathy (CIPN) is a significant problem for cancer patients, and there are limited treatment options for this often debilitating condition. Neuromodulatory interventions could be a novel modality for patients trying to manage CIPN symptoms; however, they are not yet the standard of care. This study examined whether electroencephalogram (EEG) neurofeedback (NFB) could alleviate CIPN symptoms in survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This was a randomized controlled trial with survivors assigned to an NFB group or a wait\u2010list control (WLC) group. The NFB group underwent 20 sessions of NFB, in which visual and auditory rewards were given for voluntary changes in EEGs. The Brief Pain Inventory (BPI) worst\u2010pain item was the primary outcome. The BPI, the Pain Quality Assessment Scale, and EEGs were collected before NFB and again after treatment. Outcomes were assessed with general linear modeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Cancer survivors with CIPN (average duration of symptoms, 25.3 mo), who were mostly female and had a mean age of 62.5 years, were recruited between April 2011 and September 2014. One hundred percent of the participants starting the NFB program completed it (30 in the NFB group and 32 in the WLC group). The NFB group demonstrated greater improvement than the controls on the BPI worst\u2010pain item (mean change score, \u20132.43 [95% confidence interval, \u20133.58 to \u20131.28] vs 0.09 [95% confidence interval, \u20130.72 to \u20130.90]; <jats:italic>P<\/jats:italic> =\u00b7.001; effect size, 0.83).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>NFB appears to be effective at reducing CIPN symptoms. There was evidence of neurological changes in the cortical location and in the bandwidth targeted by the intervention, and changes in EEG activity were predictive of symptom reduction. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:1989\u20131997<\/jats:bold>. \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30649","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T10:02:43Z","timestamp":1488535363000},"page":"1989-1997","source":"Crossref","is-referenced-by-count":58,"title":["Randomized controlled trial of neurofeedback on chemotherapy\u2010induced peripheral neuropathy: A pilot study"],"prefix":"10.1002","volume":"123","author":[{"given":"Sarah","family":"Prinsloo","sequence":"first","affiliation":[{"name":"Department of Palliative Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Novy","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Driver","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall","family":"Lyle","sequence":"additional","affiliation":[{"name":"Department of Marriage and Family Therapy Mount Mercy University Cedar Rapids Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois","family":"Ramondetta","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston 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