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Dasatinib has superior preclinical activity in comparison with other tyrosine kinase inhibitors against cells with the most common KIT mutation, exon 11<jats:sup>L576P<\/jats:sup>. The ECOG\u2010ACRIN E2607 trial assessed dasatinib in patients with these melanoma subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Patients received 70 mg of oral dasatinib twice daily. The primary objective for this 2\u2010stage phase 2 trial was response rate. Stage I was open to KIT+ and wild\u2010type KIT (KIT\u2013) mucosal, acral, and CSD melanoma (n = 57). Stage II accrued only KIT+ tumors (n = 30). To enrich the trial for KIT+ tumors, vulvovaginal melanoma was added, and CSD melanoma was removed from eligibility. Secondary objectives included progression\u2010free survival (PFS), overall survival (OS), and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>From May 2009 to December 2010, the first stage enrolled 57 patients. Among the evaluable patients, 3 of 51 (5.9%) achieved a partial response: all were KIT\u2013. Stage II closed early because of slow accrual (November 2011 to December 2015). In stage II, 4 of 22 evaluable patients (18.2%) had a partial response; the median duration was 4.2 months. The median PFS was 2.1 months (n = 73; 95% confidence interval [CI], 1.5\u20102.9 months). The median OS was 7.5 months (95% CI, 6.0\u201011.9 months). In exploratory analyses, no differences were seen in PFS or OS with the KIT status or subtype. Dasatinib was discontinued because of adverse events in 9 of 75 patients (12%).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The dasatinib response rate among KIT+ melanoma patients was low. In view of its clinical activity, it is recommended that imatinib remain the KIT tyrosine kinase inhibitor of choice for unresectable KIT+ melanoma. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:2688\u201097<\/jats:bold>. \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30663","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T06:32:24Z","timestamp":1490337144000},"page":"2688-2697","source":"Crossref","is-referenced-by-count":113,"title":["A phase 2 trial of dasatinib in patients with locally advanced or stage IV mucosal, acral, or vulvovaginal melanoma: A trial of the ECOG\u2010ACRIN Cancer Research Group (E2607)"],"prefix":"10.1002","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1583-3553","authenticated-orcid":false,"given":"Kevin","family":"Kalinsky","sequence":"first","affiliation":[{"name":"Columbia University Medical Center New York New 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