{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:03:32Z","timestamp":1773975812753,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T00:00:00Z","timestamp":1494547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Novartis Pharmaceuticals"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,9,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>In the adult population with newly diagnosed chronic myeloid leukemia (CML), variant translocations are usually not considered to be impairing the prognosis, whereas some additional cytogenetic abnormalities (ACAs) are associated with a negative impact on survival. Because of the rarity of CML in the pediatric population, such abnormalities have not been investigated in a large group of children with CML.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The prognostic relevance of variant t(9;22) and ACAs at diagnosis was assessed in 301 children with CML in the chronic phase who were enrolled in the International Registry for Chronic Myeloid Leukemia in Children and Adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Overall, 19 children (6.3%) presented with additional cytogenetic findings at diagnosis: 5 children (1.7%) had a variant t(9;22) translocation, 13 children (4.3%) had ACAs, and 1 had both. At 3 years, for children with a classic translocation, children with ACAs, and children with a variant t(9;22) translocation who were treated with imatinib as frontline therapy, the probability of progression\u2010free survival (PFS) was 95% (95% confidence interval [CI], 91%\u201097%), 100%, and 75% (95% CI, 13%\u201096%), respectively, and the probability of overall survival (OS) was 98% (95% CI, 95%\u2010100%), 100% (95% CI, 43%\u201098%), and 75% (95% CI, 13%\u201096%), respectively. No statistical difference was observed between the patients with classic cytogenetic findings and those with additional chromosomal abnormalities in terms of PFS and OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In contrast to adults with CML, additional chromosomal abnormalities observed at diagnosis do not seem to have a significant prognostic impact. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:3609\u201016.<\/jats:bold> \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30767","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T07:06:51Z","timestamp":1494572811000},"page":"3609-3616","source":"Crossref","is-referenced-by-count":28,"title":["Additional cytogenetic abnormalities and variant t(9;22) at the diagnosis of childhood chronic myeloid leukemia: The experience of the <scp>I<\/scp>nternational <scp>R<\/scp>egistry for <scp>C<\/scp>hronic <scp>M<\/scp>yeloid <scp>L<\/scp>eukemia in <scp>C<\/scp>hildren and <scp>A<\/scp>dolescents"],"prefix":"10.1002","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8912-4776","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Millot","sequence":"first","affiliation":[{"name":"INSERM Clinical Investigation Center 1402 Poitiers University Poitiers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christelle","family":"Dupraz","sequence":"additional","affiliation":[{"name":"INSERM Clinical Investigation Center 1402 Poitiers University Poitiers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joelle","family":"Guilhot","sequence":"additional","affiliation":[{"name":"INSERM Clinical Investigation Center 1402 Poitiers University Poitiers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meinolf","family":"Suttorp","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Carl 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