{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:37:49Z","timestamp":1791653869215,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T00:00:00Z","timestamp":1494374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372409"],"award-info":[{"award-number":["81372409"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,9,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Chemotherapy, target therapy, and immunotherapy are increasingly being used in the systematic treatment of nasopharyngeal carcinoma (NPC), during which the occurrence of hepatitis B virus (HBV) reactivation might increase. However, data regarding HBV screening and reactivation and the clinical management of NPC patients with HBV infections are lacking. This study was aimed at clarifying the risk of reactivation for NPC patients on different regimens while providing evidence concerning HBV screening and management in an endemic area.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>With the NPC database from an established big\u2010data intelligence platform at Sun Yat\u2010Sen University Cancer Center in China, NPC patients who were diagnosed between 2008 and 2016 and underwent HBV screening and regular monitoring of liver enzymes and HBV deoxyribonucleic acid (DNA) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Among the 46,919 patients identified, the HBV screening rate was 24.8% (11,616 of 46,919). Among the screened patients with an HBV infection, regular monitoring of liver enzymes and HBV DNA occurred for 563 patients. The incidence of HBV reactivation and HBV\u2010related hepatitis was 9.1% (51 of 563) and 2.5% (14 of 563), respectively. The reactivation risk varied for different treatments and regimens and ranged from 0.0% to 21.4%. Detectable baseline HBV DNA (odds ratio [OR], 2.93; <jats:italic>P<\/jats:italic> &lt; .01), the presence of liver metastasis at diagnosis (OR, 7.19; <jats:italic>P<\/jats:italic> &lt; .01), and antiviral prophylaxis (OR, 0.29; <jats:italic>P<\/jats:italic> &lt; .01) were significantly associated with reactivation.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In NPC patients with chronic HBV infections on high\u2010risk regimens, the reactivation risk is similar to or exceeds the risk associated with other immunosuppressive therapies for which screening and prophylaxis are recommended. Our findings, therefore, support HBV screening and prophylaxis for these patients, whereas regular monitoring might be appropriate for patients with resolved HBV infections or those receiving low\u2010risk regimens. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:3540\u20109.<\/jats:bold> \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30775","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T12:33:03Z","timestamp":1494419583000},"page":"3540-3549","source":"Crossref","is-referenced-by-count":54,"title":["Hepatitis B virus screening and reactivation and management of patients with nasopharyngeal carcinoma: A large\u2010scale, big\u2010data intelligence platform\u2013based analysis from an endemic area"],"prefix":"10.1002","volume":"123","author":[{"given":"Jia\u2010Wei","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Sun Yat\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Pei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Sun Yat\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Dan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Sun Yat\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou People's Republic of 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Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010Hua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sun Yat\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Sun Yat\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5888-2929","authenticated-orcid":false,"given":"Ying","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Sun Yat\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_8_3_1","first-page":"381","article-title":"Nasopharyngeal carcinoma incidence and mortality in China in 2010","volume":"33","author":"Wei KR","year":"2014","journal-title":"Chin J Cancer."},{"key":"e_1_2_8_4_1","article-title":"What is the best treatment of locally advanced nasopharyngeal carcinoma? 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