{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:03:43Z","timestamp":1789077823041,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA155101"],"award-info":[{"award-number":["R01CA155101"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA014089"],"award-info":[{"award-number":["P30CA014089"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The landscape of hereditary syndromes and clinicopathologic characteristics among US Latino\/Hispanic individuals with colorectal cancer (CRC) remains poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 265 patients with CRC who were enrolled in the Hispanic Colorectal Cancer Study were included in the current study. Information regarding CRC risk factors was elicited through interviews, and treatment and survival data were abstracted from clinical charts. Tumor studies and germline genetic testing results were collected from medical records or performed using standard molecular methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The mean age of the patients at the time of diagnosis was 53.7 years (standard deviation, 10.3 years), and 48.3% were female. Overall, 21.2% of patients reported a first\u2010degree or second\u2010degree relative with CRC; 3.4% met Amsterdam I\/II criteria. With respect to Bethesda guidelines, 38.5% of patients met at least 1 criterion. Of the 161 individuals who had immunohistochemistry and\/or microsatellite instability testing performed, 21 (13.0%) had mismatch repair (MMR)\u2010deficient (dMMR) tumors. dMMR tumors were associated with female sex (61.9%), earlier age at the time of diagnosis (50.4 \u00b1 12.4 years), proximal location (61.9%), and first\u2010degree (23.8%) or second\u2010degree (9.5%) family history of CRC. Among individuals with dMMR tumors, 13 (61.9%) had a germline MMR mutation (MutL homolog 1 [<jats:italic>MLH1<\/jats:italic>] in 6 patients; MutS homolog 2 [<jats:italic>MSH2<\/jats:italic>] in 4 patients; MutS homolog 6 [<jats:italic>MHS6<\/jats:italic>] in 2 patients; and PMS1 homolog 2, mismatch repair system component [<jats:italic>PMS2]<\/jats:italic> in 1 patient). The authors identified 2 additional <jats:italic>MLH1<\/jats:italic> mutation carriers by genetic testing who had not received immunohistochemistry\/microsatellite instability testing. In total, 5.7% of the entire cohort were confirmed to have Lynch syndrome. In addition, 6 individuals (2.3%) had a polyposis phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The percentage of dMMR tumors noted among Latino individuals (13%) is similar to estimates in non\u2010Hispanic white individuals. In the current study, the majority of individuals with dMMR tumors were confirmed to have Lynch syndrome. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017<\/jats:bold>. \u00a9 2017 The Authors. <jats:italic>Cancer<\/jats:italic> published by Wiley Periodicals, Inc. on behalf of <jats:italic>American Cancer Society<\/jats:italic>. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:3732\u20133743.<\/jats:bold> \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30790","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T10:08:37Z","timestamp":1498126117000},"page":"3732-3743","source":"Crossref","is-referenced-by-count":24,"title":["DNA mismatch repair deficiency and hereditary syndromes in Latino patients with colorectal cancer"],"prefix":"10.1002","volume":"123","author":[{"given":"Charit\u00e9 N.","family":"Ricker","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Medical Oncology Norris Comprehensive Cancer Center, University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana L.","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Medical Oncology Norris Comprehensive Cancer Center, University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Keck School of Medicine, University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Keck School of Medicine, University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana C.","family":"Stern","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Keck School of Medicine, University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Schmit","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Medical Oncology Norris Comprehensive Cancer Center, University of Southern California Los Angeles California"},{"name":"Department of Preventive Medicine Keck School of Medicine, University of Southern California Los Angeles California"},{"name":"Department of Cancer Epidemiology Moffitt Cancer Center Tampa Florida"},{"name":"Department of Gastrointestinal Oncology Moffitt Cancer Center Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg E.","family":"Idos","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastrointestinal and Liver Disease, Norris Comprehensive Cancer Center, University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Medical Oncology Norris Comprehensive Cancer Center, University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Medical Oncology Norris Comprehensive Cancer Center, University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Medical Oncology Norris Comprehensive Cancer Center, University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Medical Oncology Norris Comprehensive Cancer Center, University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Shamasunadara","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Medical Oncology Norris Comprehensive Cancer Center, University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsaneh","family":"Barzi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Medical Oncology Norris Comprehensive Cancer Center, University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz\u2010Josef","family":"Lenz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Medical Oncology Norris Comprehensive Cancer Center, University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2452-3194","authenticated-orcid":false,"given":"Jane C.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Medical Oncology Norris Comprehensive Cancer Center, University of Southern California Los Angeles California"},{"name":"Department of Preventive Medicine Keck School of Medicine, University of Southern California Los Angeles California"},{"name":"Department of Medicine Samuel Oschin Comprehensive Cancer Institute, Cedars\u2010Sinai Medical Center Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.5527"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21204"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000199918.31226.f8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2454-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24340"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-013-2707-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.04.015"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-015-0691-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25822"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22664"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.060"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.12.064"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804588"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.237"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.01.054"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012242"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(91)90093-A"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.5950"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043146"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8945"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.03.037"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-009-9310-4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02053699"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70510-X"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.23.1758"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh034"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2012.03.002"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115052108"},{"key":"e_1_2_8_30_1","first-page":"1","article-title":"Implementing Multiple Comparisons on Pearson Chi\u2010square Test for an R\u00d7C Contingency Table in SAS\u00ae","volume":"1544","author":"Jin M","year":"2014","journal-title":"SAS Global Forum Proceedings."},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25486"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1897-4287-11-18"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181d0c114"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-010-9373-2"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-005-4523-7"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-015-9795-y"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.22.1831"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.12.023"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0517"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.11.013"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq011"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.08.041"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.12.002"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4419"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20079"},{"key":"e_1_2_8_46_1","unstructured":"Pew Research Center.Hispanic population and origin in select U.S. metropolitan areas 2014.http:\/\/www.pewhispanic.org\/interactives\/hispanic\u2010population\u2010in\u2010select\u2010u\u2010s\u2010metropolitan\u2010areas\/. Accessed December 21 2016."},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25432"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10696"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2014.1756"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.30790","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.30790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T21:42:43Z","timestamp":1760305363000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.30790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,22]]},"references-count":48,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1002\/cncr.30790"],"URL":"https:\/\/doi.org\/10.1002\/cncr.30790","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,22]]}}}