{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:03:05Z","timestamp":1788436985403,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA021765\u201030"],"award-info":[{"award-number":["P30 CA021765\u201030"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Outcomes for children with acute myeloid leukemia (AML) have improved over the past 20 years even though the medications used for induction therapy have not changed.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This study analyzed data from patients with AML who were enrolled in successive protocols (AML97 and AML02) to determine the contributors to the improved outcomes of the latter clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>There were significant improvements in 5\u2010year overall survival (48.9% vs 71.2%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001) and event\u2010free survival (43.5% vs 61.8%; <jats:italic>P<\/jats:italic>\u2009=\u2009.002) from AML97 to AML02. The 5\u2010year cumulative incidence of early death (ED)\/treatment\u2010related mortality (TRM) was reduced for patients treated in AML02 (18.5% vs 7.9%; <jats:italic>P<\/jats:italic>\u2009=\u2009.007). Although the overall incidence of refractory disease (6.5% vs 5.6%; <jats:italic>P<\/jats:italic>\u2009=\u2009.736) and relapse (29.3% vs 21.0%; <jats:italic>P<\/jats:italic>\u2009=\u2009.12) did not differ between the 2 studies, patients with low\u2010risk AML who were treated in AML02 had a reduced incidence of relapse (27.3% vs 8.8%; <jats:italic>P<\/jats:italic>\u2009=\u2009.036).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The improved outcomes of the AML02 trial resulted from improved disease control for low\u2010risk patients and overall decreased ED\/TRM. These results emphasize the importance of supportive\u2010care measures throughout chemotherapy courses and hematopoietic cell transplantation and the value of treatment intensity for patients with low\u2010risk AML while underscoring the need for novel therapy, rather than increased therapy intensity, for children with high\u2010risk AML. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:3791\u20133798.<\/jats:bold> \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30791","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T10:26:55Z","timestamp":1496140015000},"page":"3791-3798","source":"Crossref","is-referenced-by-count":56,"title":["Decreased relapsed rate and treatment\u2010related mortality contribute to improved outcomes for pediatric acute myeloid leukemia in successive clinical trials"],"prefix":"10.1002","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0484-1574","authenticated-orcid":false,"given":"Thomas B.","family":"Alexander","sequence":"first","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital Memphis Tennessee"},{"name":"Department of Pediatrics University of North Carolina Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital Memphis Tennessee"},{"name":"Department of Pediatrics, College of Medicine University of Tennessee Health Science Center Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon M.","family":"Triplett","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation and Cellular Therapy St. Jude Children's Research Hospital Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9167-2114","authenticated-orcid":false,"given":"Stanley","family":"Pounds","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul C.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital Memphis Tennessee"},{"name":"Department of Pediatrics, College of Medicine University of Tennessee Health Science Center Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Hon","family":"Pui","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital Memphis Tennessee"},{"name":"Department of Pediatrics, College of Medicine University of Tennessee Health Science Center Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Rubnitz","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital Memphis Tennessee"},{"name":"Department of Pediatrics, College of Medicine University of Tennessee Health Science Center Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.8289"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.30"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70090-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2307\/2530904"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176344198"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176350951"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-364661"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.8997"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.1947"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","unstructured":"RascheM ZimmermannM KellerstrassL CreutzigU KlusmannJ ReinhardtD.Successes and challenges of pediatric AML: a report on survival salvage therapy and causes of deaths in the AML\u2010BFM Study Group from 1987\u20102012. Paper presented at: American Society of Hematology Annual Conference; December 3\u20106 2016; San Diego CA.","DOI":"10.1182\/blood.V128.22.450.450"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.153"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24739"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.276"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-261800"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28334"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08389.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403665"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.01.191"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28688"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23563"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.10.001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.02.021"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.30791","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.30791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T21:42:45Z","timestamp":1760305365000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.30791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,30]]},"references-count":23,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1002\/cncr.30791"],"URL":"https:\/\/doi.org\/10.1002\/cncr.30791","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,30]]}}}