{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:40:04Z","timestamp":1779201604009,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P01CA049639"],"award-info":[{"award-number":["P01CA049639"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Tumor protein 53 (<jats:italic>TP53<\/jats:italic>) mutations are uncommon in adult patients with acute lymphoblastic leukemia (ALL) and predict a poor outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p><jats:italic>TP53<\/jats:italic> mutation analysis was performed in 164 newly diagnosed adult patients with ALL using a combination of targeted amplicon\u2010based next\u2010generation sequencing and Sanger sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p><jats:italic>TP53<\/jats:italic> mutations were detected in 25 patients (15%), with a median allelic frequency of 42.2% (range, 5.6%\u201093.8%). The majority of mutations were single\u2010nucleotide variants of missense type and involved the DNA\u2010binding domain. <jats:italic>TP53<\/jats:italic>\u2010mutated (<jats:italic>TP53<jats:sup>mut<\/jats:sup><\/jats:italic>) ALL was found to be significantly associated with older age, lower median white blood cell and platelet counts, lower frequency of Philadelphia chromosome and a higher frequency of low hypodiploid karyotype compared with ALL with wild\u2010type <jats:italic>TP53<\/jats:italic> (<jats:italic>TP53<jats:sup>wt<\/jats:sup><\/jats:italic>). To evaluate the prognostic effect of <jats:italic>TP53<\/jats:italic> mutations, the authors selected 146 patients with B\u2010cell immunophenotype ALL (24 with <jats:italic>TP53<jats:sup>mut<\/jats:sup><\/jats:italic> and 122 with <jats:italic>TP53<jats:sup>wt<\/jats:sup><\/jats:italic>) who were uniformly treated with frontline hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper\u2010CVAD)\u2010based regimens; &gt;90% of these individuals also received a monoclonal antibody. Over a median follow\u2010up duration of 15 months, there was no significant difference in the median overall survival, event\u2010free survival, and duration of complete remission noted between patients with <jats:italic>TP53<jats:sup>mut<\/jats:sup><\/jats:italic> ALL and those with <jats:italic>TP53<jats:sup>wt<\/jats:sup><\/jats:italic> ALL.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Hyper\u2010CVAD\u2010based regimens appear to negate the poor prognostic impact of <jats:italic>TP53<\/jats:italic> mutations in patients with adult B\u2010cell immunophenotype ALL. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:3717\u201024<\/jats:bold>. \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30810","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T10:16:56Z","timestamp":1497349016000},"page":"3717-3724","source":"Crossref","is-referenced-by-count":22,"title":["<i>TP53<\/i> mutation does not confer a poor outcome in adult patients with acute lymphoblastic leukemia who are treated with frontline hyper\u2010CVAD\u2010based regimens"],"prefix":"10.1002","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7829-5249","authenticated-orcid":false,"given":"Rashmi","family":"Kanagal\u2010Shamanna","sequence":"first","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2735-168X","authenticated-orcid":false,"given":"Preetesh","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of 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