{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:35:17Z","timestamp":1787312117690,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100013873","name":"Government of Ontario","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013873","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012665","name":"Institute for Clinical Evaluative Sciences (ICES)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012665","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000226","name":"Ontario Ministry of Health and Long-Term Care (MOHLTC)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Little is known about opioid prescribing among individuals who have survived cancer. Our aim is to examine a predominantly socio\u2010economically disadvantaged population for differences in opioid prescribing rates among cancer survivors compared with matched controls without a prior diagnosis of cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This was a retrospective population\u2010wide matched cohort study. Starting in 2010, individuals residing in Ontario, Canada, who were 18 to 64 years of age and at least 5 years past their cancer diagnosis were matched to controls without a prior cancer diagnosis based on sex and calendar year of birth. Follow\u2010up was terminated at any indication of cancer recurrence, second malignancy, or new cancer diagnosis. To examine the association between survivorship and the rate of opioid prescriptions, an Andersen\u2010Gill recurrent event regression model was implemented, adjusting for numerous individual\u2010level characteristics and also accounting for the matched design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The rate of opioid prescribing was 1.22 times higher among survivors than among their corresponding matched controls (adjusted relative rate, 1.22; 95% CI, 1.11\u20101.34). Individuals from lower income quintiles who were younger, were from rural neighborhoods, and had more comorbidities had significantly higher prescribing rates. Sex was not associated with prescribing rates. This increased rate of opioid prescribing was also seen among survivors who were 10 or more years past their cancer diagnosis (compared with their controls).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      This study demonstrates substantially higher opioid prescribing rates among cancer survivors, even long after attaining survivorship. This raises concerns about the diagnosis and management of chronic pain problems among survivors stemming from their cancer diagnosis or treatment.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2017;123:4286\u20134293.\n                      <\/jats:bold>\n                      \u00a9\n                      <jats:italic>2017 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.30839","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T01:07:00Z","timestamp":1502068020000},"page":"4286-4293","source":"Crossref","is-referenced-by-count":89,"title":["Cancer survivorship and opioid prescribing rates: A population\u2010based matched cohort study among individuals with and without a history of cancer"],"prefix":"10.1002","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0320-6042","authenticated-orcid":false,"given":"Rinku","family":"Sutradhar","sequence":"first","affiliation":[{"name":"Department of Biostatistics Dalla Lana School of Public Health, University of Toronto Toronto Ontario Canada"},{"name":"Institute for Clinical Evaluative Sciences, Toronto Toronto Ontario Canada"},{"name":"Institute of Health Policy Management and Evaluation, University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armend","family":"Lokku","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Dalla Lana School of Public Health, University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Barbera","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences, Toronto Toronto Ontario Canada"},{"name":"Institute of Health Policy Management and Evaluation, University of Toronto Toronto Ontario Canada"},{"name":"Department of Radiation Oncology University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.0383"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181cf8341"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.05.017"},{"key":"e_1_2_8_5_1","first-page":"269","article-title":"Cancer survivors: United States, 2007","volume":"60","author":"Centers for Disease Control and Prevention","year":"2011","journal-title":"MMWR Morb Mortal Wkly Rep."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e31818f5aa7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25761"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.52.4629"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00355-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2010.05.013"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2190\/PM.40.2.c"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-016-1529-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.08.006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-012-0250-x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181c43103"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.5206"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2016.014837"},{"key":"e_1_2_8_18_1","volume-title":"Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non\u2010Cancer Pain","year":"2010"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/876306"},{"key":"e_1_2_8_20_1","first-page":"e92","article-title":"Clustering of opioid prescribing and opioid\u2010related mortality among family physicians in Ontario","volume":"57","author":"Dhalla IA","year":"2011","journal-title":"Can Fam Physician."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.117"},{"key":"e_1_2_8_22_1","first-page":"e13","article-title":"Trends in opioid use and dosing among socio\u2010economically disadvantaged patients","volume":"5","author":"Gomes T","year":"2011","journal-title":"Open Med."},{"key":"e_1_2_8_23_1","first-page":"246","volume-title":"Cancer Registration Principles and Methods","author":"Clarke EA","year":"1991"},{"key":"e_1_2_8_24_1","volume-title":"Living and dying in Ontario: an opportunity for improved health information. 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