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Previous genome\u2010wide association studies have identified many possible susceptible loci associated with sporadic HBV\u2010related HCC. However, despite family history being a well\u2010known risk factor for HBV\u2010related HCC, to the authors' knowledge its genetic mechanisms and associating loci remain largely unknown or unexplored, most likely due to the relative rarity of familial HCC and the difficulty of sample collection.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors conducted a genome\u2010wide association study with 139 male cases with familial HBV\u2010related HCC and 139 non\u2010HCC male controls with chronic HBV. The results were corroborated further with an independent cohort of 101 patients with familial HBV\u2010related HCC and comparison with both the 1000 Genomes Project and the Taiwan Biobank.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 51 risk single\u2010nucleotide polymorphisms (<jats:italic>P<\/jats:italic>\u22641E\u201004) were identified in the association analyses, which included 2 clusters of associated single\u2010nucleotide polymorphisms and haplotypes at 1q25.3 (glutamate\u2010ammonia ligase [<jats:italic>GLUL<\/jats:italic>]\/transmembrane epididymal protein 1 [<jats:italic>TEDDM1<\/jats:italic>]\/long intergenic non\u2010protein\u2010coding RNA 272 [<jats:italic>LINC00272<\/jats:italic>]\/regulator of G\u2010protein signaling\u2010like 1 [<jats:italic>RGSL1<\/jats:italic>]) and 17q11.2 (solute carrier family 13 member 2 [<jats:italic>SLC13A2<\/jats:italic>]\/forkhead box N1 [<jats:italic>FOXN1<\/jats:italic>]). Both the <jats:italic>GLUL<\/jats:italic> and <jats:italic>SLC13A2<\/jats:italic>\/<jats:italic>FOXN1<\/jats:italic> haplotypes have large effect sizes and were found to be different from those found from genome\u2010wide association studies of sporadic HCCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>To the authors' knowledge, the current study is the first genome\u2010wide association study to identify genetic factors for familial HBV\u2010related HCC. The results identified 2 large effect susceptible haplotypes located at <jats:italic>GLUL<\/jats:italic> and <jats:italic>SLC13A2<\/jats:italic>\/<jats:italic>FOXN1<\/jats:italic>. The current study findings also suggest different genetic susceptibility between familial and sporadic HBV\u2010related HCC. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:3966\u201076<\/jats:bold>. \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30851","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T12:26:17Z","timestamp":1498739177000},"page":"3966-3976","source":"Crossref","is-referenced-by-count":31,"title":["Genome\u2010wide association analysis identifies a <i>GLUL<\/i> haplotype for familial hepatitis B virus\u2010related hepatocellular carcinoma"],"prefix":"10.1002","volume":"123","author":[{"given":"You\u2010Yu","family":"Lin","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medicine National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Whei","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Ming","family":"Lin","sequence":"additional","affiliation":[{"name":"Liver Research Unit Chang Gung Memorial Hospital, Chang Gung University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shou\u2010Dong","family":"Lee","sequence":"additional","affiliation":[{"name":"Faculty of Medicine National Yang\u2010Ming University School of Medicine Taipei Taiwan"},{"name":"Division of Gastroenterology Department of Medicine, Cheng Hsin General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding\u2010Shinn","family":"Chen","sequence":"additional","affiliation":[{"name":"Hepatitis Research Center National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8316-3785","authenticated-orcid":false,"given":"Pei\u2010Jer","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine National Taiwan University Taipei 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