{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:44:25Z","timestamp":1790484265556,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:00:00Z","timestamp":1498694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Patients with recurrent and\/or metastatic, radioactive iodine\u2010refractory thyroid carcinoma have limited treatment options. Sorafenib, an oral kinase inhibitor, is approved by the US Food and Drug Administration for the treatment of radioactive iodine\u2010refractory thyroid carcinoma, although it demonstrated low response rates (12.2%) as a single agent in the first\u2010line setting. The objective of the current study was to determine whether adding the mammalian target of rapamycin inhibitor temsirolimus to sorafenib could improve on these results.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>In this single\u2010institution, phase 2 study, 36 patients with metastatic, radioactive iodine\u2010refractory thyroid carcinoma of follicular origin received treatment with the combination of oral sorafenib (200 mg twice daily) and intravenous temsirolimus (25 mg weekly). The receipt of prior systemic treatment with cytotoxic chemotherapy and targeted therapy, including sorafenib, was permitted. The primary endpoint was the radiographic response rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The best response was a partial response in 8 patients (22%), stable disease in 21 (58%), and progressive disease in 1 (3%). Six patients were not evaluable for a response. Patients who had received any prior systemic treatment had a response rate of 10% compared with 38% of those who had not received prior systemic treatment. One of 2 patients with anaplastic thyroid cancer had an objective response. The progression\u2010free survival rate at 1 year was 30.5%. The most common grade 3 and 4 toxicities associated with sorafenib and temsirolimus included hyperglycemia, fatigue, anemia, and oral mucositis.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Sorafenib and temsirolimus appear to be an active combination in patients with radioactive iodine\u2010refractory thyroid carcinoma, especially in patients who received no prior treatment compared with historic data from single\u2010agent sorafenib. Activity is also observed in patients who previously received sorafenib. This regimen warrants further investigation. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:4114\u20134121.<\/jats:bold> \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30861","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T12:26:44Z","timestamp":1498739204000},"page":"4114-4121","source":"Crossref","is-referenced-by-count":70,"title":["Phase 2 study evaluating the combination of sorafenib and temsirolimus in the treatment of radioactive iodine\u2010refractory thyroid cancer"],"prefix":"10.1002","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4960-4783","authenticated-orcid":false,"given":"Eric J.","family":"Sherman","sequence":"first","affiliation":[{"name":"Department of Medicine Memorial Sloan\u2010Kettering Cancer Center New York New York"},{"name":"Department of Medicine Weill Cornell Medicine New York New 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