{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:28:30Z","timestamp":1790872110986,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T00:00:00Z","timestamp":1499212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Existing data supporting the use of proton\u2010beam therapy (PBT) for limited\u2010stage small cell lung cancer (LS\u2010SCLC) are limited to a single 6\u2010patient case series. This is the first prospective study to evaluate clinical outcomes and toxicities of PBT for LS\u2010SCLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This study prospectively analyzed patients with primary, nonrecurrent LS\u2010SCLC definitively treated with PBT and concurrent chemotherapy from 2011 to 2016. Clinical backup intensity\u2010modulated radiotherapy (IMRT) plans were generated for each patient and were compared with PBT plans. Outcome measures included local control (LC), recurrence\u2010free survival (RFS), and overall survival (OS) rates and toxicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Thirty consecutive patients were enrolled and evaluated. The median dose was 63.9 cobalt gray equivalents (range, 45\u201066.6 cobalt gray equivalents) in 33 to 37 fractions delivered daily (n = 18 [60.0%]) or twice daily (n = 12 [40.0%]). The concurrent chemotherapy was cisplatin\/etoposide (n = 21 [70.0%]) or carboplatin\/etoposide (n = 9 [30.0%]). In comparison with the backup IMRT plans, PBT allowed statistically significant reductions in the cord, heart, and lung mean doses and the volume receiving at least 5 Gy but not in the esophagus mean dose or the lung volume receiving at least 20 Gy. At a median follow\u2010up of 14 months, the 1\u2010\/2\u2010year LC and RFS rates were 85%\/69% and 63%\/42%, respectively. The median OS was 28.2 months, and the 1\u2010\/2\u2010year OS rates were 72%\/58%. There was 1 case each (3.3%) of grade 3 or higher esophagitis, pneumonitis, anorexia, and pericardial effusion. Grade 2 pneumonitis and esophagitis were seen in 10.0% and 43.3% of patients, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In the first prospective registry study and largest analysis to date of PBT for LS\u2010SCLC, PBT was found to be safe with a limited incidence of high\u2010grade toxicities. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:4244\u20134251.<\/jats:bold> \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30870","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T10:06:41Z","timestamp":1499249201000},"page":"4244-4251","source":"Crossref","is-referenced-by-count":44,"title":["Prospective study of proton\u2010beam radiation therapy for limited\u2010stage small cell lung cancer"],"prefix":"10.1002","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2180-1280","authenticated-orcid":false,"given":"Jean\u2010Claude 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