{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:29:49Z","timestamp":1783380589245,"version":"3.54.6"},"reference-count":60,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T00:00:00Z","timestamp":1503619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K05 CA152715"],"award-info":[{"award-number":["K05 CA152715"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K07 CA172298"],"award-info":[{"award-number":["K07 CA172298"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UM1 CA167551"],"award-info":[{"award-number":["UM1 CA167551"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2 TR000421"],"award-info":[{"award-number":["KL2 TR000421"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005895","name":"Fred Hutchinson Cancer Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Body weight is associated with colorectal cancer (CRC) risk and survival, but to the authors' knowledge, the impact of long\u2010term postdiagnostic weight change is unclear. Herein, the authors investigated whether weight change over the 5 years after a diagnosis of CRC is associated with survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>CRC cases diagnosed from 1997 to 2008 were identified through 4 population\u2010based cancer registry sites. Participants enrolled within 2 years of diagnosis and reported their height and weight 2 years prior. Follow\u2010up questionnaires were administered approximately 5 years after diagnosis. Associations between change in weight (in kg) or body mass index (BMI) with overall and CRC\u2010specific survival were estimated using Cox regression analysis adjusted for age, sex, American Joint Committee on Cancer stage of disease, baseline BMI, nonsteroidal anti\u2010inflammatory drug use, smoking, time between diagnosis and enrollment, and study site.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>At the 5\u2010year postdiagnostic survey, 2049 participants reported higher (53%; median plus 5 kg), unchanged (12%), or lower (35%; median \u20104 kg) weight. Over a median of 5.1 years of subsequent follow\u2010up (range, 0.3\u20109.9 years), 344 participants died (91 of CRC). Long\u2010term weight loss (per 5 kg) was found to be associated with poorer overall survival (hazard ratio, 1.13; 95% confidence interval, 1.07\u20101.21) and CRC\u2010specific survival (hazard ratio, 1.25; 95% confidence interval, 1.13\u20101.39). Significantly lower survival was similarly observed for relative weight loss (&gt;5% vs \u22645% change), BMI reduction (per 1 unit), or BMI category change (overweight to normal vs remaining overweight).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Weight loss 5 years after a diagnosis of CRC was found to be significantly associated with decreased long\u2010term survival, suggesting the importance of avoiding weight loss in survivors of CRC. Future research should attempt to further evaluate this association, accounting for whether this weight change was intentional or represents a marker of declining health. <jats:bold><jats:italic>Cancer<\/jats:italic> 2017;123:4701\u20104708<\/jats:bold>. \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30932","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T10:36:44Z","timestamp":1503657404000},"page":"4701-4708","source":"Crossref","is-referenced-by-count":35,"title":["Long\u2010term weight loss after colorectal cancer diagnosis is associated with lower survival: The Colon Cancer Family Registry"],"prefix":"10.1002","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8084-1608","authenticated-orcid":false,"given":"Jonathan M.","family":"Kocarnik","sequence":"first","affiliation":[{"name":"Public Health Sciences Fred Hutchinson Cancer Research Center Seattle Washington"},{"name":"Institute of Translational Health Sciences Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwei","family":"Hua","sequence":"additional","affiliation":[{"name":"Public Health Sciences Fred Hutchinson Cancer Research Center Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Hardikar","sequence":"additional","affiliation":[{"name":"Public Health Sciences Fred Hutchinson Cancer Research Center Seattle Washington"},{"name":"Department of Epidemiology University of Washington Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamaica","family":"Robinson","sequence":"additional","affiliation":[{"name":"Public Health Sciences Fred Hutchinson Cancer Research Center Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noralane M.","family":"Lindor","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Scottsdale Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aung Ko","family":"Win","sequence":"additional","affiliation":[{"name":"Melbourne School of Population and Global Health The University of Melbourne Melbourne Victoria Australia"},{"name":"Centre for Cancer Research Victorian Comprehensive Cancer Centre Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Hopper","sequence":"additional","affiliation":[{"name":"Melbourne School of Population and Global Health The University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2452-3194","authenticated-orcid":false,"given":"Jane C.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine University of Southern California Los Angeles California"},{"name":"Samuel Oschin Comprehensive Cancer Institute Cedars\u2010Sinai Medical Center Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Potter","sequence":"additional","affiliation":[{"name":"Public Health Sciences Fred Hutchinson Cancer Research Center Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Epidemiology Research Program American Cancer Society Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Gallinger","sequence":"additional","affiliation":[{"name":"Prevention and Cancer Control Cancer Care Ontario Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Cotterchio","sequence":"additional","affiliation":[{"name":"Prevention and Cancer Control Cancer Care Ontario Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott V.","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Division of Oncology University of Washington Seattle Washington"},{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda I.","family":"Phipps","sequence":"additional","affiliation":[{"name":"Public Health Sciences Fred Hutchinson Cancer Research Center Seattle Washington"},{"name":"Department of Epidemiology University of Washington Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8786-0043","authenticated-orcid":false,"given":"Polly A.","family":"Newcomb","sequence":"additional","affiliation":[{"name":"Public Health Sciences Fred Hutchinson Cancer Research Center Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,25]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"FerlayJ SoerjomataramI ErvikM et al eds.GLOBOCAN 2012: estimated cancer incidence mortality and prevalence worldwide in 2012 v.1.0: IARC CancerBase No. 11.http:\/\/globocan.iarc.fr. Accessed February 24 2016."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-12-1356"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.8699"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.70.5327"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm5030243"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-013-0276-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-304701"},{"key":"e_1_2_8_9_1","volume-title":"Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective","author":"World Cancer Research Fund\/American Institute for Cancer Research","year":"2007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq011"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.172"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-1059"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.0287"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0094"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12140"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30163"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0732"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu357"},{"issue":"3","key":"e_1_2_8_19_1","article-title":"Adult weight gain and adiposity\u2010related cancers: a dose\u2010response meta\u2010analysis of prospective observational studies","volume":"107","author":"Keum N","year":"2015","journal-title":"J Natl Cancer Inst."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.6687"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0145"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0079"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2015.07.002"},{"key":"e_1_2_8_24_1","unstructured":"Colon Cancer Family Registry.http:\/\/www.coloncfr.org\/. Accessed July 20 2017."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0648"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4275"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26114"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0039"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30446"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_8_31_1","volume-title":"International Classification of Diseases","author":"World Health Organization","year":"2010"},{"key":"e_1_2_8_32_1","first-page":"1","article-title":"Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee","volume":"854","year":"1995","journal-title":"World Health Organ Tech Rep Ser."},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.65"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470258019"},{"key":"e_1_2_8_35_1","volume-title":"Stata Statistical Software: Release 14","author":"StataCorp LLC","year":"2015"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-014-0450-y"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21265"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27938"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv073"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.1440"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.4051"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2014.0137"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2009.0058"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-1336"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-12-0306"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0150"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5237-9"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601781"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-014-0393-3"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.200"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0764"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0439"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.87"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/2042-6410-3-13"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2010.00298.x"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.9735"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28208"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437739.71477.ee"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800365"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737167.2014.891441"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.30932","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.30932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T17:18:11Z","timestamp":1760289491000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.30932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,25]]},"references-count":60,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/cncr.30932"],"URL":"https:\/\/doi.org\/10.1002\/cncr.30932","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,25]]}}}