{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:20:30Z","timestamp":1788787230317,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007423","name":"Lyda Hill Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01ES011740"],"award-info":[{"award-number":["R01ES011740"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA131274"],"award-info":[{"award-number":["R01CA131274"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2017,12,15]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Because of the current epidemic of human papillomavirus (HPV)\u2013related oropharyngeal cancer (OPC), a screening strategy is urgently needed. The presence of serum antibodies to HPV\u201016 early (E) antigens is associated with an increased risk for OPC. The purpose of this study was to evaluate the diagnostic accuracy of antibodies to a panel of HPV\u201016 E antigens in screening for OPC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This case\u2010control study included 378 patients with OPC, 153 patients with nonoropharyngeal head and neck cancer (non\u2010OPC), and 782 healthy control subjects. The tumor HPV status was determined with p16 immunohistochemistry and HPV in situ hybridization. HPV\u201016 E antibody levels in serum were identified with an enzyme\u2010linked immunosorbent assay. A trained binary logistic regression model based on the combination of all E antigens was predefined and applied to the data set. The sensitivity and specificity of the assay for distinguishing HPV\u2010related OPC from controls were calculated. Logistic regression analysis was used to calculate odds ratios with 95% confidence intervals for the association of head and neck cancer with the antibody status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Of the 378 patients with OPC, 348 had p16\u2010positive OPC. HPV\u201016 E antibody levels were significantly higher among patients with p16\u2010positive OPC but not among patients with non\u2010OPC or among controls. Serology showed high sensitivity and specificity for HPV\u2010related OPC (binary classifier: 83% sensitivity and 99% specificity for p16\u2010positive OPC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      A trained binary classification algorithm that incorporates information about multiple E antibodies has high sensitivity and specificity and may be advantageous for risk stratification in future screening trials.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2017;123:4886\u201094\n                      <\/jats:bold>\n                      . \u00a9\n                      <jats:italic>2017 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.30955","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T12:22:01Z","timestamp":1505218921000},"page":"4886-4894","source":"Crossref","is-referenced-by-count":22,"title":["Diagnostic accuracy of serum antibodies to human papillomavirus type 16 early antigens in the detection of human papillomavirus\u2013related oropharyngeal cancer"],"prefix":"10.1002","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8116-9558","authenticated-orcid":false,"given":"Kristina R.","family":"Dahlstrom","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen S.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Center for Personalized Diagnostics, Biodesign Institute Arizona State University Tempe Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Field","sequence":"additional","affiliation":[{"name":"Center for Personalized Diagnostics, Biodesign Institute Arizona State University Tempe Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Chowell","sequence":"additional","affiliation":[{"name":"Center for Personalized Diagnostics, Biodesign Institute Arizona State University Tempe Arizona"},{"name":"Simon A. Levin Mathematical, Computational, and Modeling Sciences Center Arizona State University Tempe Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyi","family":"Wei","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute Duke University Medical Center Durham North Carolina"},{"name":"Department of Medicine Duke University School of Medicine Durham North 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