{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:28:51Z","timestamp":1789673331274,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grants-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Science, Sports, Culture and Technology of Japan","award":["17015018"],"award-info":[{"award-number":["17015018"]}]},{"name":"Grants-in-Aid for Scientific Research from Japan Society for the Promotion of Science","award":["26860430"],"award-info":[{"award-number":["26860430"]}]},{"name":"Grant-in-Aid for the Third Term Comprehensive 10-year Strategy for Cancer Control from the Ministry of Health, Labor and Welfare of Japan","award":["27-A-4"],"award-info":[{"award-number":["27-A-4"]}]},{"name":"National Cancer Center Research and Development Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Major salivary gland cancers (M\u2010SGCs) are rare, and have distinct heterogeneous histopathological subtypes. To the authors' knowledge, no consistent evidence of an association between cigarette smoking and the risk of M\u2010SGCs has appeared to date. Furthermore, evidence of potential heterogeneity in the impact of smoking on histopathological subtypes is scarce, despite the fact that the histopathological subtypes of M\u2010SGC exhibit different genetic features.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors conducted a case\u2010control study to investigate the association between smoking and M\u2010SGC by histopathological subtype. Cases were 81 patients with M\u2010SGCs and the controls were 810 age\u2010matched and sex\u2010matched first\u2010visit outpatients without cancer treated at Aichi Cancer Center Hospital from 1988 to 2005. Odds ratios (OR) and 95% confidence intervals (95% CI) were assessed by conditional logistic regression analysis with adjustment for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Smoking was found to be associated with a significantly increased risk of M\u2010SGC overall, with an OR of 3.45 (95% CI, 1.58\u20107.51; <jats:italic>P<\/jats:italic> =.001) for heavy smokers compared with never\u2010smokers. A significant dose\u2010response relationship was observed (<jats:italic>P<\/jats:italic> for trend, .001). When stratified by histological subtype, no obvious impact of smoking was observed among patients with mucoepidermoid carcinoma (MEC). In contrast, smoking demonstrated a significantly increased risk of M\u2010SGCs other than MEC, with an OR of 5.15 (95% CI, 2.06\u201012.87; <jats:italic>P<\/jats:italic>&lt;.001) for heavy smokers compared with never\u2010smokers. The authors observed possible heterogeneity with regard to the impact of smoking on risk between MEC and M\u2010SGCs other than MEC (<jats:italic>P<\/jats:italic> for heterogeneity, .052).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The results of the current study demonstrate a significant positive association between cigarette smoking and the risk of M\u2010SGC overall. However, the impact of smoking appeared to be limited to M\u2010SGCs other than MEC. <jats:bold><jats:italic>Cancer<\/jats:italic> 2018;124:118\u201024<\/jats:bold>. \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.30957","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T15:55:10Z","timestamp":1504799710000},"page":"118-124","source":"Crossref","is-referenced-by-count":28,"title":["Heterogeneous impact of smoking on major salivary gland cancer according to histopathological subtype: A case\u2010control study"],"prefix":"10.1002","volume":"124","author":[{"given":"Michi","family":"Sawabe","sequence":"first","affiliation":[{"name":"Division of Molecular and Clinical Epidemiology Aichi Cancer Center Research Institute Nagoya Japan"},{"name":"Department of Otolaryngology Head and Neck Surgery, Nagoya City Univercity Graduate School of Medicine Nagoya 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