{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:58:26Z","timestamp":1790481506594,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T00:00:00Z","timestamp":1507593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Breast cancer risk estimates for atypical lesions are based primarily on case\u2010control studies of patients with open biopsies. The authors report the cumulative breast cancer incidence after a core biopsy diagnosis of atypical hyperplasia (ductal or lobular) or lobular carcinoma in situ.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A cohort study with central pathology review was conducted on 393 patients who had core biopsy diagnoses of atypical hyperplasia and lobular carcinoma in situ from 1995 through 2010. Follow\u2010up was available for 255 of 264 patients (97%) at a median of 87 months (range, 3\u2010236 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>There were 212 patients (54%) who were not upgraded on excision and had no personal history of breast cancer. Of these, 21 of 212 (9.9%) developed breast cancer, including 15 invasive carcinomas, 4 ductal carcinomas in situ, 1 pleomorphic lobular carcinoma in situ, and 1 unknown type. The prior core biopsy diagnoses were atypical ductal hyperplasia for 11 patients (52%) and atypical lobular hyperplasia\/lobular carcinoma in situ in the remaining 10 patients (48%). The number of atypical foci in the core biopsy was not significantly associated with the subsequent development of breast cancer (<jats:italic>P<\/jats:italic>\u2009=\u2009.42). Of the 15 invasive carcinomas, 11 (73%) were ipsilateral, 11 (73%) were pathologic T1 tumors, 5 (33%) were pathologic N1 tumors, 13 (87%) were estrogen receptor\u2010positive, and 1 (7%) was amplified for human epidermal growth factor receptor 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In patients who had an initial diagnosis of atypical hyperplasia or lobular carcinoma in situ on core biopsy, the 7\u2010year cumulative breast cancer incidence was 9.9%. Most tumors were ipsilateral, stage I, estrogen receptor\u2010positive, invasive carcinomas. The current data support close clinical and radiologic follow\u2010up for more than 5 years in this patient population. <jats:bold><jats:italic>Cancer<\/jats:italic> 2018;124:459\u201065<\/jats:bold>. \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.31061","type":"journal-article","created":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T12:16:41Z","timestamp":1507637801000},"page":"459-465","source":"Crossref","is-referenced-by-count":32,"title":["Breast cancer risk associated with atypical hyperplasia and lobular carcinoma in situ initially diagnosed on core\u2010needle biopsy"],"prefix":"10.1002","volume":"124","author":[{"given":"Alana R.","family":"Donaldson","sequence":"first","affiliation":[{"name":"Department of Pathology Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Division of Breast Services\u2010Department of General Surgery Digestive Disease and Surgery Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazia","family":"Goraya","sequence":"additional","affiliation":[{"name":"Division of Breast Services\u2010Department of General Surgery Digestive Disease and Surgery Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly J.","family":"Pederson","sequence":"additional","affiliation":[{"name":"Division of Breast Services\u2010Department of General Surgery Digestive Disease and Surgery Institute, Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0153-498X","authenticated-orcid":false,"given":"Charles D.","family":"Sturgis","sequence":"additional","affiliation":[{"name":"Department of Pathology Robert J. 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