{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:04:26Z","timestamp":1788923066694,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:00:00Z","timestamp":1510012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA193249"],"award-info":[{"award-number":["CA193249"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA140933"],"award-info":[{"award-number":["CA140933"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA109298"],"award-info":[{"award-number":["CA109298"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG017265"],"award-info":[{"award-number":["AG017265"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG043404"],"award-info":[{"award-number":["AG043404"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA086862"],"award-info":[{"award-number":["P30CA086862"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Social factors in the patient macroenvironment have been shown to influence molecular events in the tumor microenvironment and thereby influence cancer progression. However, biomarkers providing a window into the longitudinal effects of biobehavioral factors on tumor biology over time are lacking. Exosome analysis is a novel strategy for in vivo monitoring of dynamic changes in tumor cells. This study examined exosomal profiles from patients with low or high levels of social support for epithelial\u2010mesenchymal transition (EMT) polarization and gene expression related to inflammation and \u03b2\u2010adrenergic signaling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Exosomes were isolated from plasma sampled from a series of 40 women before primary surgical resection of advanced\u2010stage, high\u2010grade ovarian carcinoma. Samples were selected for analysis on the basis of extremes of low and high levels of social support. After exosomal isolation and RNA extraction, a microarray analysis of the transcriptome was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Primary analyses identified significant upregulation of 67 mesenchymal\u2010characteristic gene transcripts and downregulation of 63 epithelial\u2010characteristic transcripts in patients with low social support; this demonstrated increased EMT polarization (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.0002). Secondary analyses using promoter sequence bioinformatics supported a priori hypotheses linking low social support to 1) increased activity of cyclic adenosine monophosphate response element binding protein (CREB)\/activating transcription factor (ATF) family transcription factors that mediate the \u03b2\u2010adrenergic response to catecholamines via the cyclic adenosine monophosphate\/protein kinase A signaling pathway (mean fold change for CREB: 2.24\u2009\u00b1\u20090.65;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.0019; mean fold change for ATF: 2.00\u2009\u00b1\u20090.55;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.0049) and 2) increased activity of the proinflammatory nuclear factor \u03baB\/Rel family of transcription factors (mean fold change: 2.10\u2009\u00b1\u20090.70;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.0109).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      These findings suggest the possibility of leveraging exosomes as a noninvasive assessment of biobehavioral factors to help to direct personalized treatment approaches.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2018;124:580\u20106.\n                      <\/jats:bold>\n                      \u00a9\n                      <jats:italic>2017 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31078","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T09:34:00Z","timestamp":1510047240000},"page":"580-586","source":"Crossref","is-referenced-by-count":33,"title":["Biobehavioral modulation of the exosome transcriptome in ovarian carcinoma"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3793-5881","authenticated-orcid":false,"given":"Susan K.","family":"Lutgendorf","sequence":"first","affiliation":[{"name":"Department of Psychological and Brain Sciences University of Iowa Iowa City Iowa"},{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology University of Iowa Iowa City Iowa"},{"name":"Department of Urology University of Iowa Iowa City Iowa"},{"name":"Holden Comprehensive Cancer Center University of Iowa Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premal H.","family":"Thaker","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesusa M.","family":"Arevalo","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, David Geffen School of Medicine University of California Los Angeles California"},{"name":"Cousins Center for Psychoneuroimmunology University of California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Goodheart","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology University of Iowa Iowa City Iowa"},{"name":"Holden Comprehensive Cancer Center University of Iowa Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George M.","family":"Slavich","sequence":"additional","affiliation":[{"name":"Cousins Center for Psychoneuroimmunology University of California Los Angeles California"},{"name":"Department of Psychiatry and Biobehavioral Sciences University of California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology The University of Texas MD Anderson Cancer Center Houston Texas"},{"name":"Department of Cancer Biology The University of Texas MD Anderson Cancer Center Houston Texas"},{"name":"Center for RNA Interference and Noncoding RNA The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve W.","family":"Cole","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, David Geffen School of Medicine University of California Los Angeles California"},{"name":"Cousins Center for Psychoneuroimmunology University of California Los Angeles California"},{"name":"Department of Psychiatry and Biobehavioral Sciences University of California Los Angeles 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