{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:25:02Z","timestamp":1790007902492,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T00:00:00Z","timestamp":1508198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Mucosal melanomas in the head and neck region are most often located in the nasal cavity and paranasal sinuses. To the authors' knowledge, the prognostic effects of lymph node metastasis in patients with sinonasal mucosal melanoma (SNMM) have not been established. Therefore, the objective of the current study was to determine the effects of lymph node metastasis on survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The current study included 198 patients with SNMM who had been treated between 1985 and 2016 at The University of Texas MD Anderson Cancer Center in Houston. Patients' clinical and pathologic lymph node statuses were evaluated and characterized. A multivariate analysis was used to assess the associations between regional spread and survival outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Therapeutic neck dissection was performed in 23 patients with SNMM (11.6%). Regional disease recurrence occurred in 7 of the patients who had lymph node metastasis at the time of presentation (30.4%) and in 30 of those who had N0 disease at the time of presentation (17.1%) (<jats:italic>P\u2009=\u2009<\/jats:italic>.15). Metastasis to the contralateral lymph nodes was present in 7 patients (3.5%). The 5\u2010year disease\u2010specific survival rate was 66% in patients with lymph node spread compared with 45% in patients with N0 status (<jats:italic>P\u2009=\u2009<\/jats:italic>.04, log\u2010rank test). A multivariate analysis demonstrated that distant metastasis was the only variable found to be independently associated with both overall survival (hazard ratio, 2.96; 95% confidence interval, 1.54\u20106.95 [<jats:italic>P\u2009=\u2009<\/jats:italic>.01]) and disease\u2010specific survival (hazard ratio, 3.32; 95% confidence interval, 1.79\u20107.14 [<jats:italic>P\u2009=\u2009<\/jats:italic>0.01]).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The results of the current study demonstrated that lymph node status in patients with SNMM was not a significant predictor of outcome. This finding, together with the low incidence of lymph node metastases in patients with SNMM, suggests that elective treatment of the neck should be highly selective in this patient population. <jats:bold><jats:italic>Cancer<\/jats:italic> 2018;124:514\u201020.<\/jats:bold> \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.31083","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T09:03:12Z","timestamp":1508230992000},"page":"514-520","source":"Crossref","is-referenced-by-count":41,"title":["Approaches to regional lymph node metastasis in patients with head and neck mucosal melanoma"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9720-7766","authenticated-orcid":false,"given":"Moran","family":"Amit","sequence":"first","affiliation":[{"name":"Division of Surgery, Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1145-5185","authenticated-orcid":false,"given":"Samantha","family":"Tam","sequence":"additional","affiliation":[{"name":"Division of Surgery, Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed S.","family":"Abdelmeguid","sequence":"additional","affiliation":[{"name":"Division of Surgery, Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"},{"name":"Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine Mansoura University Mansoura City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianna B.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Division of Surgery, Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaan M.","family":"Raza","sequence":"additional","affiliation":[{"name":"Division of Surgery, Department of Neurosurgery The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley Y.","family":"Su","sequence":"additional","affiliation":[{"name":"Division of Surgery, Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Kupferman","sequence":"additional","affiliation":[{"name":"Division of Surgery, Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"DeMonte","sequence":"additional","affiliation":[{"name":"Division of Surgery, Department of Neurosurgery The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehab Y.","family":"Hanna","sequence":"additional","affiliation":[{"name":"Division of Surgery, Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23355"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000035"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24976"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.6004\/jnccn.2012.0038","article-title":"Controversies in the management of regional nodes in melanoma","volume":"10","author":"Plitas G","year":"2012","journal-title":"J Natl Compr Canc Netw"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2007.30"},{"key":"e_1_2_8_8_1","unstructured":"National Comprehensive Cancer Network.Head and neck cancer (version 2.2016).https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head-and-neck.pdf. Accessed October 26 2016."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.5.536"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2011.11.006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2012.04.023"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(99)00085-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10019"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80554-9"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900701)66:1<109::AID-CNCR2820660120>3.0.CO;2-A"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.04.006"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(00)80121-0"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.1.73"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200202000-00002"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.31083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.31083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T21:39:37Z","timestamp":1760305177000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.31083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,17]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/cncr.31083"],"URL":"https:\/\/doi.org\/10.1002\/cncr.31083","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,17]]}}}