{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T15:40:19Z","timestamp":1781192419237,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T00:00:00Z","timestamp":1541808000000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["5U10HL069294"],"award-info":[{"award-number":["5U10HL069294"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["HHSH25020120016C"],"award-info":[{"award-number":["HHSH25020120016C"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["5U24\u2010CA076518"],"award-info":[{"award-number":["5U24\u2010CA076518"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000006","name":"Office of Naval Research","doi-asserted-by":"publisher","award":["N00014\u201015\u20101\u20100848"],"award-info":[{"award-number":["N00014\u201015\u20101\u20100848"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000006","name":"Office of Naval Research","doi-asserted-by":"publisher","award":["N00014\u201016\u20101\u20102020"],"award-info":[{"award-number":["N00014\u201016\u20101\u20102020"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,2,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Autologous hematopoietic cell transplantation (auto\u2010HCT) is a standard therapy for relapsed classic Hodgkin lymphoma (cHL) and diffuse large B\u2010cell lymphoma (DLBCL); however, long\u2010term outcomes are not well described.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This study analyzed survival, nonrelapse mortality, late effects, and subsequent malignant neoplasms (SMNs) in 1617 patients who survived progression\u2010free for \u22652 years after auto\u2010HCT for cHL or DLBCL between 1990 and 2008. The median age at auto\u2010HCT was 40 years; the median follow\u2010up was 10.6 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The 5\u2010year overall survival rate was 90% (95% confidence interval [CI], 87%\u201092%) for patients with cHL and 89% (95% CI, 87%\u201091%) for patients with DLBCL. The risk of late mortality in comparison with the general population was 9.6\u2010fold higher for patients with cHL (standardized mortality ratio [SMR], 9.6) and 3.4\u2010fold higher for patients with DLBCL (SMR, 3.4). Relapse accounted for 44% of late deaths. At least 1 late effect was reported for 9% of the patients. A total of 105 SMNs were confirmed: 44 in the cHL group and 61 in the DLBCL group. According to a multivariate analysis, older age, male sex, a Karnofsky score &lt; 90, total body irradiation (TBI) exposure, and a higher number of lines of chemotherapy before auto\u2010HCT were risk factors for overall mortality in cHL. Risk factors in DLBCL were older age and TBI exposure. A subanalysis of 798 adolescent and young adult patients mirrored the outcomes of the overall study population.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Despite generally favorable outcomes, 2\u2010year survivors of auto\u2010HCT for cHL or DLBCL have an excess late\u2010mortality risk in comparison with the general population and experience an assortment of late complications. <jats:bold><jats:italic>Cancer<\/jats:italic> 2018;124:816\u201025<\/jats:bold>. \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.31114","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T08:08:37Z","timestamp":1510301317000},"page":"816-825","source":"Crossref","is-referenced-by-count":51,"title":["Long\u2010term outcomes among 2\u2010year survivors of autologous hematopoietic cell transplantation for Hodgkin and diffuse large b\u2010cell lymphoma"],"prefix":"10.1002","volume":"124","author":[{"given":"Regina M.","family":"Myers","sequence":"first","affiliation":[{"name":"Divisions of Hematology and Oncology The Children's Hospital of Philadelphia Philadelphia Pennsylvania Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Cleveland Clinic Taussig Cancer Institute Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3317-1896","authenticated-orcid":false,"given":"Bronwen E.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research Department of Medicine, Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1404-0575","authenticated-orcid":false,"given":"Soyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research Department of Medicine, Medical College of Wisconsin Milwaukee Wisconsin"},{"name":"Division of Biostatistics, Institute for Health and Society Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather R.","family":"Millard","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research Department of Medicine, Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoo","family":"Battiwalla","sequence":"additional","affiliation":[{"name":"Hematology Branch National Heart, Lung, and Blood Institute Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7082-891X","authenticated-orcid":false,"given":"Navneet S.","family":"Majhail","sequence":"additional","affiliation":[{"name":"Blood and Marrow Transplant Program Cleveland Clinic Taussig Cancer Institute Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Buchbinder","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Children's Hospital of Orange County Orange California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillard M.","family":"Lazarus","sequence":"additional","affiliation":[{"name":"Seidman Cancer Center, University Hospitals Cleveland Medical Center Case Western Reserve University Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3304-9965","authenticated-orcid":false,"given":"Bipin N.","family":"Savani","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E. 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