{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:11:25Z","timestamp":1790244685711,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Cachexia, described as weight loss (mainly in lean body mass [LBM]) and anorexia, is common in patients with advanced cancer. This study examined the efficacy and safety of anamorelin (ONO\u20107643), a novel selective ghrelin receptor agonist, in Japanese cancer patients with cachexia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This double\u2010blind clinical trial (ONO\u20107643\u201004) enrolled 174 patients with unresectable stage III\/IV non\u2013small cell lung cancer (NSCLC) and cachexia in Japan. Patients were randomized to daily oral anamorelin (100\u2009mg) or a placebo for 12 weeks. The primary endpoint was the change from the baseline LBM (measured with dual\u2010energy x\u2010ray absorptiometry) over 12 weeks. The secondary endpoints were changes in appetite, body weight, quality of life, handgrip strength (HGS), and 6\u2010minute walk test (6MWT) results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The least squares mean change (plus or minus the standard error) in LBM from the baseline over 12 weeks was 1.38\u2009\u00b1\u20090.18 and \u22120.17\u2009\u00b1\u20090.17\u2009kg in the anamorelin and placebo groups, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.0001). Changes from the baseline in LBM, body weight, and anorexia symptoms showed significant differences between the 2 treatment groups at all time points. Anamorelin increased prealbumin at weeks 3 and 9. No changes in HGS or 6MWT were detected between the groups. Twelve weeks' treatment with anamorelin was safe and well tolerated in NSCLC patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Anamorelin significantly increased LBM and improved anorexia symptoms and the nutritional state, but not motor function, in Japanese patients with advanced NSCLC. Because no effective treatment for cancer cachexia is currently available, anamorelin can be a beneficial treatment option.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2018;124:606\u201016.\n                      <\/jats:bold>\n                      \u00a9 2017 The Authors.\n                      <jats:italic>Cancer<\/jats:italic>\n                      published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution\u2010NonCommercial\u2010NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non\u2010commercial and no modifications or adaptations are made.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31128","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T06:37:05Z","timestamp":1512455825000},"page":"606-616","source":"Crossref","is-referenced-by-count":224,"title":["Anamorelin (ONO\u20107643) for the treatment of patients with non\u2013small cell lung cancer and cachexia: Results from a randomized, double\u2010blind, placebo\u2010controlled, multicenter study of Japanese patients (ONO\u20107643\u201004)"],"prefix":"10.1002","volume":"124","author":[{"given":"Nobuyuki","family":"Katakami","sequence":"first","affiliation":[{"name":"Division of Integrated Oncology, Institute of Biomedical Research and Innovation Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Uchino","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Kyoto Prefectural University of Medicine Kyoto Japan"},{"name":"Department of Respiratory Medicine Fukuoka University School of Medicine Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuma","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kyorin University Hospital Mitaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tateaki","family":"Naito","sequence":"additional","affiliation":[{"name":"Division of Thoracic Oncology Shizuoka Cancer Center Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Nagoya University Nagoya Japan"},{"name":"Department of Respiratory Medicine Fujita Health University Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouzo","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Kanagawa Cancer Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromoto","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Shikoku Cancer Center Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Yoshimori","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Japan Anti\u2010Tuberculosis Association Fukujuji Hospital Kiyose Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagaoka Red Cross Hospital Nagaoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Aichi Cancer Center Aichi Hopital Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Aoe","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Hospital Organization Yamaguchi\u2010Ube Medical Center Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Takiguchi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Graduate School of Medicine, Chiba University Chiba 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