{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:03:31Z","timestamp":1773299011095,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T00:00:00Z","timestamp":1510876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Although an association between hepatitis C virus (HCV) infection and oropharyngeal cancers (OPCs) has been reported, to the authors' knowledge the clinical significance of this epidemiological finding remains unknown. Therefore, the authors analyzed the oncologic outcomes of HCV\u2010infected patients with OPCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>In this retrospective cohort study, all patients with OPCs who were seen at The University of Texas MD Anderson Cancer Center between January 2004 and December 2015 were reviewed. HCV infection was defined as detectable HCV RNA in the serum. Five\u2010year overall survival and progression\u2010free survival rates were compared between patients infected with HCV and those not infected.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 161 patients were examined. The majority of the patients were white (141 patients; 88%) and male (132 patients; 82%) and had TNM stage III or IV disease (147 patients; 91%). The OPC involved the tonsils (83 patients; 52%), base of the tongue (67patients; 42%), or the soft palate (11 patients; 7%). The median follow\u2010up after an OPC diagnosis was 3 years (range, 1\u201013 years). HCV\u2010infected patients (25 patients) and HCV\u2010uninfected patients (136 patients) were comparable with regard to smoking and alcohol status. In multivariate analysis, HCV was associated with increased cancer\u2010specific mortality (hazard ratio, 2.15; 95% confidence interval, 1.08\u20106.85 [<jats:italic>P<\/jats:italic>\u2009=\u2009.02]) and risk of OPC progression (hazard ratio, 5.42; 95% confidence interval, 2.64\u201011.14 [<jats:italic>P<\/jats:italic>\u2009=\u2009.0008]) independent of age and cirrhosis status. Antivirals were administered after the diagnosis of OPC in 8 of the 25 HCV\u2010infected patients (32%). HCV\u2010infected patients who received antivirals were found to have better 5\u2010year overall survival (70% vs 12%; <jats:italic>P<\/jats:italic>\u2009=\u2009.005) and progression\u2010free survival (72% vs 19%; <jats:italic>P<\/jats:italic>\u2009=\u2009.005) compared with patients who did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The early detection of HCV is important in patients with OPC because this infection may affect their oncologic outcomes. <jats:bold><jats:italic>Cancer<\/jats:italic> 2018;124:960\u20105.<\/jats:bold> \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.31146","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T11:52:37Z","timestamp":1510919557000},"page":"960-965","source":"Crossref","is-referenced-by-count":9,"title":["Impact of chronic hepatitis C virus infection on the survival of patients with oropharyngeal cancer"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4625-421X","authenticated-orcid":false,"given":"Minas P.","family":"Economides","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moran","family":"Amit","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1285-3310","authenticated-orcid":false,"given":"Parag S.","family":"Mahale","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4193-1587","authenticated-orcid":false,"given":"Jeff J.","family":"Hosry","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uddalak","family":"Bharadwaj","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1069-4822","authenticated-orcid":false,"given":"Erich M.","family":"Sturgis","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harrys A.","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center Houston Texas"},{"name":"Department of Gastroenterology, Hepatology and Nutrition The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12123"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21403"},{"key":"e_1_2_8_4_1","first-page":"1","article-title":"Biological agents. 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