{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:11:55Z","timestamp":1790745115605,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006364","name":"Institut National du Cancer","doi-asserted-by":"publisher","award":["INCa_6291"],"award-info":[{"award-number":["INCa_6291"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,3,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The objective of this study was to describe characteristics at diagnosis and outcomes of adults with soft tissue sarcoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors conducted a retrospective multicenter study of 12,262 patients who were treated between January 1980 and 31 December 2013 in French Sarcoma Group centers and enrolled in the \u201cConticabase.\u201d Diagnoses were systematically reviewed by expert pathologists, and entities were classified according to the 2013 World Health Organization classification. Diagnostic characteristics, treatments, and outcomes are described for the entire cohort, for the subgroup of patients with translocation\u2010related sarcomas, and for 9 different histologic subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The results stressed the magnitude of heterogeneity among adult sarcomas. For example, compared with other sarcomas, translocation\u2010related sarcomas (2143 tumors; 20.8%) were associated with a younger age at presentation (40.6 vs 60.0 years; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001), a low rate of predisposing conditions (0.01% vs 22.3%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001), a higher rate of lymph node involvement (4.7% vs 1.3%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001), and a higher rate of synchronous metastasis (11.9% vs 6.7%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001); and complete (R0) resection (41.6% vs 31.9%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001), receipt of (neo)adjuvant radiation therapy (62.6% vs 42.2%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001), and receipt of (neo)adjuvant chemotherapy (36.6% vs 22.3%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001) were significantly more frequent. Overall, translocation\u2010related sarcomas were associated with a lower rate of local relapse (18.1% vs 26.0%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001) but a higher rate of metastatic relapse (42.0% vs 30.7%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Collaborative efforts are urgently needed to better assess the natural history and management options for every histologic subtype of sarcoma. <jats:bold><jats:italic>Cancer<\/jats:italic> 2018;124:1179\u201087.<\/jats:bold> \u00a9 <jats:italic>2017 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.31176","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T09:56:59Z","timestamp":1512554219000},"page":"1179-1187","source":"Crossref","is-referenced-by-count":64,"title":["Presentation and outcome of frequent and rare sarcoma histologic subtypes: A study of 10,262 patients with localized visceral\/soft tissue sarcoma managed in reference centers"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5243-1548","authenticated-orcid":false,"given":"Nicolas","family":"Penel","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Oscar Lambret Center Lille France"},{"name":"Methodology Clinical Research Platform, Lille French Comprehensive Cancer Center (SIRIC OncoLille) Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Michel","family":"Coindre","sequence":"additional","affiliation":[{"name":"Department of Biopathology, National Institute of Health and Medical Research (INSERM) Unit 916, Bergonie Institute University of Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Giraud","sequence":"additional","affiliation":[{"name":"Clinical and Epidemiologic Research Unit, INSERM Clinical Investigation Center 1401, Bergonie Institute Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Terrier","sequence":"additional","affiliation":[{"name":"Department of Pathology Gustave Roussy Institute Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Ranchere\u2010Vince","sequence":"additional","affiliation":[{"name":"Department of Biopathology Leon Berard Center Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Collin","sequence":"additional","affiliation":[{"name":"Department of Pathology Georges\u2010Francois Leclerc Center Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie L. E.","family":"Guellec","sequence":"additional","affiliation":[{"name":"Department of Pathology University Cancer Institute of Toulouse\u2010Oncopole Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Bazille","sequence":"additional","affiliation":[{"name":"Department of Pathologic Anatomy University Hospital Caen Basse\u2010Normandie France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marick","family":"Lae","sequence":"additional","affiliation":[{"name":"Department of Pathology Curie Institute Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzague","family":"de Pinieux","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Tours and Francois Rabelais University Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle L.","family":"Ray\u2010Coquard","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Leon Berard Center Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9726-9732","authenticated-orcid":false,"given":"Sylvie","family":"Bonvalot","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Surgery Gustave Roussy Institute Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel L. E.","family":"Cesne","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Surgery Gustave Roussy Institute Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves\u2010Marie","family":"Robin","sequence":"additional","affiliation":[{"name":"Department of Pathology Oscar Lambret Center Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhardt","family":"Stoeckle","sequence":"additional","affiliation":[{"name":"Department of Surgery Bergonie Institute Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3896-9274","authenticated-orcid":false,"given":"Maud","family":"Toulmonde","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Bergonie Institute Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Yves","family":"Blay","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Leon Berard Center Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041866"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0241"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh058"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr610"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt407"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.02.008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/jso.20897","article-title":"The value of expert second opinion in diagnosis of soft tissue sarcomas","volume":"97","author":"Lenhnhardt M","year":"2008","journal-title":"J Surg Oncol"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0000000000000050"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu360"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453679408993717"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600057"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2009.05.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2011.643821"},{"issue":"6","key":"e_1_2_8_15_1","article-title":"Full\u2010dose neoadjuvant anthracycline\u2009+\u2009ifosfamide chemotherapy is associated with a relapse free survival (RFS) and overall survival (OS) benefit in localized high\u2010risk adult soft tissue sarcomas (STS) of the extremities and trunk wall: interim analysis of a prospective randomized trial [abstract]","volume":"27","author":"Gronchi A","year":"2016","journal-title":"Ann Oncol"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01283-0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.4734"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.60.8505"},{"issue":"6","key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/annonc\/mdw388.03","article-title":"The nationwide cohort of 26,883 patients with sarcomas treated in NETSARC reference network between 2010 and 2015 in France: major impact of multidisciplinary board presentation prior to first treatment [abstract]","volume":"27","author":"Blay J","year":"2016","journal-title":"Ann Oncol."}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.31176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.31176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T18:31:59Z","timestamp":1760293919000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.31176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,6]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,3,15]]}},"alternative-id":["10.1002\/cncr.31176"],"URL":"https:\/\/doi.org\/10.1002\/cncr.31176","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,6]]}}}