{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T14:21:10Z","timestamp":1793715670304,"version":"4.6.1"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T00:00:00Z","timestamp":1524441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2TR000440"],"award-info":[{"award-number":["KL2TR000440"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>False\u2010positive cancer screening results may affect a patient's willingness to obtain future screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The authors conducted logistic regression analysis of 450,484 person\u2010years of electronic medical records (2006\u20102015) in 92,405 individuals aged 50 to 75 years. Exposures were false\u2010positive breast, prostate, or colorectal cancer screening test results (repeat breast imaging or negative breast biopsy \u22643 months after screening mammography, repeat prostate\u2010specific antigen [PSA] test \u22643 months after PSA test result \u22654.0 ng\/mL or negative prostate biopsy \u22643 months after any PSA result, or negative colonoscopy [without biopsy\/polypectomy] \u22646 months after a positive fecal occult blood test). Outcomes were up\u2010to\u2010date status with breast or colorectal cancer screening. Covariates included prior screening history, clinical information (eg, family history, obesity, and smoking status), comorbidity, and demographics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Women were more likely to be up to date with breast cancer screening if they previously had false\u2010positive mammography findings (adjusted odds ratio [AOR], 1.43 [95% confidence interval, 1.34\u20101.51] without breast biopsy and AOR, 2.02 [95% confidence interval, 1.56\u20102.62] with breast biopsy; both\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001). The same women were more likely to be up to date with colorectal cancer screening (AOR range, 1.25\u20101.47 depending on breast biopsy; both\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001). Men who previously had false\u2010positive PSA testing were more likely to be up to date with colorectal cancer screening (AOR, 1.22 [\n                      <jats:italic>P<\/jats:italic>\n                      = .039] without prostate imaging\/biopsy and AOR, 1.60 [\n                      <jats:italic>P<\/jats:italic>\n                      = .028] with imaging\/biopsy). Results were stronger for individuals with more false\u2010positive results (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2264.005). However, women with previous false\u2010positive colorectal cancer fecal occult blood test screening results were found to be less likely to be up to date with breast cancer screening (AOR, 0.73;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Patients who previously had a false\u2010positive breast or prostate cancer screening test were more likely to engage in future screening.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2018;124:2390\u20108\n                      <\/jats:bold>\n                      . \u00a9\n                      <jats:italic>2018 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31271","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T04:02:56Z","timestamp":1524456176000},"page":"2390-2398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Implications of false\u2010positive results for future cancer screenings"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-7104","authenticated-orcid":false,"given":"Glen B.","family":"Taksler","sequence":"first","affiliation":[{"name":"Medicine Institute Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Keating","sequence":"additional","affiliation":[{"name":"Department of Health Care Policy Harvard Medical School Boston Massachusetts"},{"name":"Division of General Internal Medicine Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Rothberg","sequence":"additional","affiliation":[{"name":"Medicine Institute Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804163381601"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.1398"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-157-2-201207170-00459"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0254"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15-0970"},{"key":"e_1_2_8_8_1","volume-title":"Benefits and Harms of Prostate\u2010Specific Antigen Screening for Prostate Cancer: An Evidence Update for the U.S. Preventive Services Task Force","author":"Lin K","year":"2008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.5989"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq099"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.1.71"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7250.1635"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-1-199907060-00002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr455"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/23.4.292"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0524"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-7-200704030-00006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-1118-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckr057"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.573"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jms.8.3.145"},{"key":"e_1_2_8_22_1","first-page":"320","article-title":"Factors affecting women's response to an invitation to attend for a second breast cancer screening examination","volume":"41","author":"Orton M","year":"1991","journal-title":"Br J Gen Pract."},{"key":"e_1_2_8_23_1","unstructured":"Optum.Real world health care experiences from over 150 million unique individuals since 1993.https:\/\/www.optum.com\/content\/dam\/optum\/resources\/productSheets\/5302_Data_Assets_Chart_Sheet_ISPOR.pdf. 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