{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T19:50:26Z","timestamp":1794340226963,"version":"4.9.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,5,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Despite recent advances in allogeneic hematopoietic stem cell transplantation (AHSCT), the outcome of patients who have acute myeloid leukemia (AML) with a complex karyotype (CK) remains poor. The objective of this study was to identify prognostic factors associated with post\u2010transplantation survival in a large cohort of patients with CK AML.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>In total, data on 1342 consecutively patients who underwent transplantation for CK (\u22653 chromosomal abnormalities) AML were provided by the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation and from the University of Texas MD Anderson Cancer Center database were included in the analysis. The median patient age was 52 years. The donors were human leukocyte antigen\u2010matched related donors (N = 749), matched unrelated donors (N = 513), and mismatched unrelated donors (N = 80).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Relapse was the main cause of treatment failure. Overall, 51% of patients relapsed, 17.6% died of treatment\u2010related mortality, and 31.3% survived leukemia\u2010free. In multivariate analysis, the factors associated with an increased risk of relapse were age (&gt;40 years; hazard ratio [HR], 1.1 per 10 years; <jats:italic>P<\/jats:italic> = .02), secondary AML (HR, 1.35; <jats:italic>P<\/jats:italic> = .01), active disease at transplantation (HR, 1.98; <jats:italic>P<\/jats:italic> &lt; .001), and deletion\/monosomy 5 (HR, 1.5; <jats:italic>P<\/jats:italic> &lt; .001); whereas age (HR, 1.15 per 10 years; <jats:italic>P<\/jats:italic> &lt; .001), secondary AML (HR, 1.36; <jats:italic>P<\/jats:italic> = .001), active disease at transplantation (HR, 1.99; <jats:italic>P<\/jats:italic> &lt; .001), deletion\/monosomy 5 (HR, 1.24; <jats:italic>P<\/jats:italic> = .008), and deletion\/monosomy 7 (HR, 1.44; <jats:italic>P<\/jats:italic> &lt; .001) predicted for leukemia\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Disease relapse remains the most common cause of treatment failure for patients with CK AML after transplantation. Novel approaches to decrease the relapse rate and improve survival are needed in these patients. <jats:bold><jats:italic>Cancer<\/jats:italic> 2018;124:2134\u201041<\/jats:bold>. \u00a9 <jats:italic>2018 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.31311","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T00:51:31Z","timestamp":1519347091000},"page":"2134-2141","source":"Crossref","is-referenced-by-count":39,"title":["Relapse and survival after transplantation for complex karyotype acute myeloid leukemia: A report from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation and the University of Texas MD Anderson Cancer Center"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8597-3271","authenticated-orcid":false,"given":"Stefan O.","family":"Ciurea","sequence":"first","affiliation":[{"name":"Department of Stem Cell Transplant and Cellular Therapy The University of Texas MD Anderson Cancer Center  Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"Acute Leukemia Working Party, European Society for Blood and Marrow Transplantation Paris Study Office\/European Center for Biostatistical and Epidemiological Evaluation in Hematopoietic Cell Therapy Paris France"},{"name":"Institute of Hematology and Oncology, Department of Hematology, Hospital Clinic, August Pi I Sunyer Institute for Biomedical Investigation (IDIBAPS) University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Socie","sequence":"additional","affiliation":[{"name":"Department of Hematology St. Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liisa","family":"Volin","sequence":"additional","affiliation":[{"name":"Department of Medicine Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Passweg","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Chevallier","sequence":"additional","affiliation":[{"name":"Department of Hematology Hotel\u2010Dieu University Hospital Center Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich","family":"Beelen","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation University Hospital, Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel","family":"Milpied","sequence":"additional","affiliation":[{"name":"Department of Hematology and Cellular Therapy Bordeaux University Hospital Center, Haut\u2010Leveque Hospital Pessac 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Transplantation Paris Study Office\/European Center for Biostatistical and Epidemiological Evaluation in Hematopoietic Cell Therapy Paris France"},{"name":"Institute of Hematology and Oncology, Department of Hematology, Hospital Clinic, August Pi I Sunyer Institute for Biomedical Investigation (IDIBAPS) University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyanuch","family":"Kongtim","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplant and Cellular Therapy The University of Texas MD Anderson Cancer Center  Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Rondon","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplant and Cellular Therapy The University of Texas MD Anderson Cancer Center  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