{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:39:44Z","timestamp":1786977584805,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K08CA207845\u201001"],"award-info":[{"award-number":["1K08CA207845\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KL2 TR000140\u2010BS"],"award-info":[{"award-number":["KL2 TR000140\u2010BS"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>\n                    A significant proportion of prostate cancer diagnoses may be associated with a strong hereditary component. Men who have multiple single\u2010gene polymorphisms and a family history of prostate cancer have a significantly greater risk of developing prostate cancer. Numerous single\u2010gene alterations have been confirmed to increase the risk of prostate cancer. These include breast cancer genes 1 and 2 (\n                    <jats:italic>BRCA1<\/jats:italic>\n                    and\n                    <jats:italic>BRCA2<\/jats:italic>\n                    , respectively), mutL homolog 1 (\n                    <jats:italic>MLH1<\/jats:italic>\n                    ), mutS homologs 2 and 6 (\n                    <jats:italic>MSH2<\/jats:italic>\n                    and\n                    <jats:italic>MSH6<\/jats:italic>\n                    , respectively), postmeiotic segregation increased 2 (\n                    <jats:italic>PMS2<\/jats:italic>\n                    ), homeobox B13 (\n                    <jats:italic>HOXB13<\/jats:italic>\n                    ), checkpoint kinase 2 (\n                    <jats:italic>CHEK2<\/jats:italic>\n                    ), nibrin (\n                    <jats:italic>NBN<\/jats:italic>\n                    ), BRCA1\u2010interacting protein C\u2010terminal helicase 1 (\n                    <jats:italic>BRIP1<\/jats:italic>\n                    ), and ataxia telangiectasia mutated (\n                    <jats:italic>ATM<\/jats:italic>\n                    ). Currently, there are no uniform guidelines on the definition of hereditary prostate cancer and genetic testing. With the advent of next\u2010generation sequencing, which is capable of testing multiple genes simultaneously, and the approval of olaparib for\n                    <jats:italic>BRCA1<\/jats:italic>\n                    \/\n                    <jats:italic>BRCA2<\/jats:italic>\n                    or\n                    <jats:italic>ATM<\/jats:italic>\n                    \u2010mutated, metastatic, castrate\u2010resistant prostate cancer, it is being recognized that the results of genetic testing have an impact on therapeutic strategies. In this review, the authors examine the role of genetic counseling and testing, the challenges of insurance coverage for testing, the available germline and somatic testing panels, and the complexity of each testing method and its implications.\n                    <jats:bold>\n                      <jats:italic>Cancer<\/jats:italic>\n                      2018.\n                    <\/jats:bold>\n                    \u00a9\n                    <jats:italic>2018 American Cancer Society<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/cncr.31316","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T13:53:37Z","timestamp":1524059617000},"page":"3105-3117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Genetic testing for hereditary prostate cancer: Current status and limitations"],"prefix":"10.1002","volume":"124","author":[{"given":"Jun Tu","family":"Zhen","sequence":"first","affiliation":[{"name":"Frank H. Netter School of Medicine at Quinnipiac University North Haven Connecticut"},{"name":"Department of Urology Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Urology Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin Anh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Urology Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Leapman","sequence":"additional","affiliation":[{"name":"Department of Urology Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Center University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Brierley","sequence":"additional","affiliation":[{"name":"Cancer Genetics and Prevention Program, Smilow Cancer Center, Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Llor","sequence":"additional","affiliation":[{"name":"Cancer Genetics and Prevention Program, Smilow Cancer Center, Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Hofstatter","sequence":"additional","affiliation":[{"name":"Cancer Genetics and Prevention Program, Smilow Cancer Center, Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2065-3570","authenticated-orcid":false,"given":"Brian","family":"Shuch","sequence":"additional","affiliation":[{"name":"Department of Urology Yale School of Medicine New Haven Connecticut"},{"name":"Cancer Genetics and Prevention Program, Smilow Cancer Center, Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007133430201"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.30"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603144"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.10301"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.6607"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00891-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0568"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.21.1600"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027130"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00780-9"},{"key":"e_1_2_9_12_1","first-page":"53","article-title":"Family history and prostate cancer risk in a population\u2010based cohort of Iowa men","volume":"8","author":"Cerhan JR","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_9_13_1","unstructured":"Surveillance Research Program National Cancer Institute.Fast Stats: an interactive tool for access to SEER cancer statistics. 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