{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:30:21Z","timestamp":1790173821338,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011621","name":"Winship Cancer Institute of Emory University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA138292"],"award-info":[{"award-number":["P30CA138292"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Risk stratification of newly diagnosed patients with mantle cell lymphoma (MCL) primarily is based on the MCL International Prognostic Index (MIPI) and Ki\u201067 proliferative index. Single\u2010center studies have reported inferior outcomes in patients with a complex karyotype (CK), but this remains an area of controversy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The authors retrospectively reviewed 483 patients from 5 academic centers in the United States and described the effect of a CK on survival outcomes in individuals with MCL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A CK was found to be associated with inferior overall survival (OS) (4.5 vs 11.6 years;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.01) and progression\u2010free survival (PFS) (1.9 vs 4.4 years;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.01). In patients who underwent high\u2010intensity induction followed by autologous stem cell transplantation (ASCT) in first remission, a CK was associated with poor OS (5.1 vs 11.6 years;\n                      <jats:italic>P<\/jats:italic>\n                      = .04) and PFS (3.6 vs 7.8 years;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.01). Among patients with a CK, high\u2010intensity induction had no effect on OS (4.5 vs 3.8 years;\n                      <jats:italic>P<\/jats:italic>\n                      = .77) nor PFS (2.3 vs 1.5 years;\n                      <jats:italic>P<\/jats:italic>\n                      = .46). Similarly, ASCT in first remission did not improve PFS (3.5 vs 1.2 years;\n                      <jats:italic>P<\/jats:italic>\n                      = .12) nor OS (5.1 vs 4.0 years;\n                      <jats:italic>P<\/jats:italic>\n                      = .27). On multivariable analyses with Ki\u201067 and MIPI, only CK was found to be predictive of OS (hazard ratio [HR], 1.98; 95% confidence interval [95% CI], 1.12\u20103.49 [\n                      <jats:italic>P<\/jats:italic>\n                      = .02]), whereas both CK (HR, 1.91; 95% CI, 1.17\u20103.12 [\n                      <jats:italic>P<\/jats:italic>\n                      = .01]) and Ki\u201067 &gt;30% (HR, 1.86; 95% CI, 1.06\u20103.28 [\n                      <jats:italic>P<\/jats:italic>\n                      = .03]) were associated with inferior PFS. Multivariable analysis did not identify any specific cytogenetic abnormalities associated with inferior survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      CK appears to be independently associated with inferior outcomes in patients with MCL regardless of the intensity of induction therapy and receipt of ASCT. Cytogenetics should be incorporated into the workup of a new diagnosis of MCL and novel therapeutic approaches should be investigated for patients with CK.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2018;124:2306\u201015\n                      <\/jats:bold>\n                      . \u00a9\n                      <jats:italic>2018 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31328","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T15:44:37Z","timestamp":1522079077000},"page":"2306-2315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Complex karyotype in patients with mantle cell lymphoma predicts inferior survival and poor response to intensive induction therapy"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2752-8078","authenticated-orcid":false,"given":"I. Brian","family":"Greenwell","sequence":"first","affiliation":[{"name":"Department of Hematology and Medical Oncology, Winship Cancer Institute Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley D.","family":"Staton","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, Winship Cancer Institute Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, Winship Cancer Institute Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Switchenko","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, Winship Cancer Institute Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra F.","family":"Saxe","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, Winship Cancer Institute Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Maly","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology The Ohio State University James Cancer Hospital Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristie A.","family":"Blum","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology The Ohio State University James Cancer Hospital Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie S.","family":"Grover","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology University of North Carolina at Chapel Hill Lineberger Cancer Center Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie P.","family":"Mathews","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina at Chapel Hill Lineberger Cancer Center Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max J.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Medicine, OHSU Knight Cancer Institute Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey V.","family":"Danilov","sequence":"additional","affiliation":[{"name":"Department of Medicine, OHSU Knight Cancer Institute Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8216-3457","authenticated-orcid":false,"given":"Narendranath","family":"Epperla","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Medical College of Wisconsin Cancer Center Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy S.","family":"Fenske","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Medical College of Wisconsin Cancer Center Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5372-510X","authenticated-orcid":false,"given":"Mehdi","family":"Hamadani","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Medical College of Wisconsin Cancer Center Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven I.","family":"Park","sequence":"additional","affiliation":[{"name":"Levine Cancer Institute Charlotte North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9524-3990","authenticated-orcid":false,"given":"Christopher 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