{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:17:32Z","timestamp":1788459452675,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011082","name":"University of North Carolina School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011082","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The purpose of the current study was to determine quality of life and tumor control from a prospective phase 2 clinical trial evaluating deintensified chemoradiotherapy for favorable risk, human papillomavirus (HPV)\u2010associated oropharyngeal squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Patients with T0\u2010T3, N0\u2010N2c, M0, p16\u2010positive disease and a minimal smoking history were treated with 60 grays of intensity\u2010modulated radiotherapy with concurrent weekly intravenous cisplatin (30 mg\/m<jats:sup>2<\/jats:sup>). The primary study endpoint was the pathologic complete response rate based on biopsy of the primary site and dissection of pretreatment positive lymph node regions. The pathologic complete response rate as previously reported was 86%. Herein, the authors report secondary endpoint measures of local control, regional control, cause\u2010specific survival, distant metastasis\u2010free survival, and overall survival, and patient\u2010reported outcomes (European Organization for Research and Treatment of Cancer [EORTC] Quality of Life Questionnaire [EORTC QLQ\u2010C30] and the Patient\u2010Reported Outcomes version of Common Terminology Criteria for Adverse Events [PRO\u2010CTCAE]).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 44 patients enrolled with a median follow\u2010up of 36 months (88% with \u22652 years). The 3\u2010year local control, regional control, cause\u2010specific survival, distant metastasis\u2010free survival, and overall survival rates were 100%, 100%, 100%, 100%, and 95%, respectively. The mean before and 3\u2010year after EORTC QOL scores were: global: 80 of 78; swallowing: 11 of 11; dry mouth: 16 of 41; and sticky saliva: 6 of 29. The mean before and 3\u2010year after PRO\u2010CTCAE scores were: swallowing: 0.4 of 0.7; and dry mouth: 0.4 of 1.4. Approximately 39% of patients required a feeding tube (median duration, 15 weeks; none were permanent). There were no \u2265grade 3 late adverse events reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>For patients with favorable\u2010risk human papillomavirus\u2010associated oropharyngeal squamous cell carcinoma, a substantially decreased intensity of therapy with 60 grays of intensity\u2010modulated radiotherapy and weekly low\u2010dose cisplatin produced better preservation of quality of life compared with standard therapies while maintaining excellent 3\u2010year tumor control and survival. <jats:bold><jats:italic>Cancer<\/jats:italic> 2018;124:2347\u201054<\/jats:bold>. \u00a9 <jats:italic>2018 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.31338","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T15:54:25Z","timestamp":1522079665000},"page":"2347-2354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":131,"title":["Mature results of a prospective study of deintensified chemoradiotherapy for low\u2010risk human papillomavirus\u2010associated oropharyngeal squamous cell carcinoma"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6775-7986","authenticated-orcid":false,"given":"Bhishamjit S.","family":"Chera","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of North Carolina School of Medicine Chapel Hill North Carolina"},{"name":"UNC Lineberger Comprehensive Cancer Center University of North Carolina Hospitals Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Amdur","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida Hospitals Gainesville Florida"},{"name":"UF Health Shands Cancer Center University of Florida Hospitals Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel E.","family":"Tepper","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of North Carolina School of Medicine Chapel Hill North Carolina"},{"name":"UNC Lineberger Comprehensive Cancer Center University of North Carolina Hospitals Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianming","family":"Tan","sequence":"additional","affiliation":[{"name":"UNC Lineberger Comprehensive Cancer Center University of North Carolina Hospitals Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-4447","authenticated-orcid":false,"given":"Jared","family":"Weiss","sequence":"additional","affiliation":[{"name":"UNC Lineberger Comprehensive Cancer Center University of North Carolina Hospitals Chapel Hill North Carolina"},{"name":"Division of Hematology Oncology, Department of Medicine University of North Carolina School of Medicine Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juneko E.","family":"Grilley\u2010Olson","sequence":"additional","affiliation":[{"name":"UNC Lineberger Comprehensive Cancer Center University of North Carolina Hospitals Chapel Hill North Carolina"},{"name":"Division of Hematology Oncology, Department of Medicine University of North Carolina School of Medicine Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Neil","family":"Hayes","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology, Department of Medicine, University of Tennessee Health Science Center Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Zanation","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery University of North Carolina School of Medicine Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor G.","family":"Hackman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery University of North Carolina School of Medicine Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samip","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery University of North Carolina School of Medicine Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Sheets","sequence":"additional","affiliation":[{"name":"Rex UNC Healthcare Raleigh North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C.","family":"Weissler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery University of North Carolina School of Medicine Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6592-2810","authenticated-orcid":false,"given":"William M.","family":"Mendenhall","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida Hospitals Gainesville Florida"},{"name":"UF Health Shands Cancer Center University of Florida Hospitals Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.8841"},{"key":"e_1_2_8_4_1","unstructured":"Radiation Therapy Oncology Group.Randomized phase II trial of transoral endoscopic head and neck surgery followed by risk\u2010based IMRT and weekly cisplatin versus IMRT and weekly cisplatin for HPV negative oropharynx cancer.http:\/\/www.rtog.org\/ClinicalTrials\/ProtocolTable\/StudyDetails.aspx?study=1221. 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