{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:45:16Z","timestamp":1790516716963,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA138292"],"award-info":[{"award-number":["P30CA138292"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Posttransplant lymphoproliferative disorder (PTLD) is a life\u2010threatening complication of solid organ transplantation. Histologic heterogeneity and a lack of treatment standards have made evaluating clinical outcomes in specific patient populations difficult. This systematic literature review investigated the impact of the PTLD histologic subtype on survival in a large data set.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Case series were identified on PubMed with the search terms <jats:italic>post\u2010transplant lymphoproliferative disorder\/disease<\/jats:italic>, <jats:italic>PTLD<\/jats:italic>, and <jats:italic>solid organ transplantation<\/jats:italic>, with additional publications identified through reference lists. The patient characteristics, immunosuppressive regimen, treatment, survival, and follow\u2010up time for 306 cases were extracted from 94 articles, and these cases were combined with 11 cases from Emory University Hospital. Patients with a recorded subtype were included in a Kaplan\u2010Meier survival analysis (n = 234). Cox proportional hazards regression analyses identified predictors of overall survival (OS) for each subtype and B\u2010cell subgroup.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>OS differed significantly between monomorphic T\u2010cell neoplasms (median, 9 months) and polymorphic, monomorphic B\u2010cell, and Hodgkin\u2010type neoplasms, for which the median OS was not reached (<jats:italic>P<\/jats:italic> = .0001). Significant differences in OS among B subgroups were not detected, but there was a trend toward decreased survival for patients with Burkitt\u2010type PTLD. Kidney transplantation and a reduction of immunosuppression were associated with increased OS for patients with B\u2010cell neoplasms in a multivariate analysis. Immunosuppression with azathioprine was associated with decreased OS for patients with T\u2010cell neoplasms, whereas radiotherapy was associated with improved OS for patients with that subtype.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The histologic subtype represents an important prognostic factor in PTLD, with patients with T\u2010cell neoplasms exhibiting very poor OS. Possibly lower survival for certain subsets of patients with B\u2010cell PTLD should be explored further and suggests the need for subtype\u2010specific therapies to improve outcomes. <jats:bold><jats:italic>Cancer<\/jats:italic> 2018;124:2327\u201036<\/jats:bold>. \u00a9 <jats:italic>2018 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.31339","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T16:01:53Z","timestamp":1522080113000},"page":"2327-2336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Impact of the posttransplant lymphoproliferative disorder subtype on survival"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4414-0489","authenticated-orcid":false,"given":"Jean L.","family":"Koff","sequence":"first","affiliation":[{"name":"Hematology and Medical Oncology, Winship Cancer Institute Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Hematology and Medical Oncology, Winship Cancer Institute Emory University Atlanta Georgia"},{"name":"Hematology, First Affiliated Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics, Winship Cancer Institute Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Switchenko","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics, Winship Cancer Institute Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9524-3990","authenticated-orcid":false,"given":"Christopher R.","family":"Flowers","sequence":"additional","affiliation":[{"name":"Hematology and Medical Oncology, Winship Cancer Institute Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund K.","family":"Waller","sequence":"additional","affiliation":[{"name":"Hematology and Medical Oncology, Winship Cancer Institute Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.56.082103.104727"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-011-0177-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.9.3633.bloodjournal8793633"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1309\/DW2TW2087BXL2BRK"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq231"},{"key":"e_1_2_8_7_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2001.00059.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01098.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0377"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11360"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10595"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01211.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70300-X"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318276a237"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03896.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/11.suppl_1.S113"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200002150-00021"},{"key":"e_1_2_8_19_1","unstructured":"NickleachD LiuY ShrewsberryA OganK KimS WangZ.SAS\u00ae macros to conduct common biostatistical analyses and generate reports. 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