{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:47:09Z","timestamp":1792615629492,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R21\u2010CA143254"],"award-info":[{"award-number":["R21\u2010CA143254"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,6,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The investigation of exercise training in metastatic breast cancer has received minimal attention. This study determined the feasibility and safety of aerobic training in metastatic breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Sixty\u2010five women (age, 21\u201080 years) with metastatic (stage IV) breast cancer (57% were receiving chemotherapy, and &gt;40% had\u2009\u2265\u20092 lines of prior therapy) were allocated to an aerobic training group (n\u2009=\u200933) or a stretching group (n\u2009=\u200932). Aerobic training consisted of 36 supervised treadmill walking sessions delivered thrice weekly between 55% and 80% of peak oxygen consumption (VO<jats:sub>2peak<\/jats:sub>) for 12 consecutive weeks. Stretching was matched to aerobic training with respect to location, frequency, duration, and intervention length. The primary endpoint was aerobic training feasibility, which was a priori defined as the lost to follow\u2010up (LTF) rate (&lt;20%) and attendance (\u226570%). Secondary endpoints were safety, objective outcomes (VO<jats:sub>2peak<\/jats:sub> and functional capacity), and patient\u2010reported outcomes (PROs; quality of life).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>One of the 33 patients (3%) receiving aerobic training was LTF, whereas the mean attendance rate was 63%\u2009\u00b1\u200930%. The rates of permanent discontinuation and dose modification were 27% and 49%, respectively. Intention\u2010to\u2010treat analyses indicated improvements in PROs, which favored the attention control group (<jats:italic>P<\/jats:italic> values\u2009&gt;\u2009.05). Per protocol analyses indicated that 14 of 33 patients (42%) receiving aerobic training had acceptable tolerability (relative dose intensity\u2009\u2265\u200970%), and this led to improvements in VO<jats:sub>2peak<\/jats:sub> and functional capacity (<jats:italic>P<\/jats:italic> values\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Aerobic training at the dose and schedule tested is safe but not feasible for a significant proportion of patients with metastatic breast cancer. The acceptable feasibility and promising benefit for select patients warrant further evaluation in a dose\u2010finding phase 1\/2 study. <jats:bold><jats:italic>Cancer<\/jats:italic> 2018;124:2552\u201060.<\/jats:bold> \u00a9 <jats:italic>2018 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.31368","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T17:36:09Z","timestamp":1523036169000},"page":"2552-2560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Feasibility, safety, and efficacy of aerobic training in pretreated patients with metastatic breast cancer: A randomized controlled trial"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-5800","authenticated-orcid":false,"given":"Jessica M.","family":"Scott","sequence":"first","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center New York New York"},{"name":"Weill Cornell Medical College New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9773-5235","authenticated-orcid":false,"given":"Neil M.","family":"Iyengar","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center New York New York"},{"name":"Weill Cornell Medical College New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tormod S.","family":"Nilsen","sequence":"additional","affiliation":[{"name":"Department of Physical Performance Norwegian School of Sport Sciences Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Michalski","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha M.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"James","family":"Herndon","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sasso","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences University of British Columbia Okanagan Kelowna British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Yu","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarat","family":"Chandarlapaty","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center New York New York"},{"name":"Weill Cornell Medical College New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chau T.","family":"Dang","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center New York New York"},{"name":"Weill Cornell Medical College New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Comen","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center New York New York"},{"name":"Weill Cornell Medical College New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura N.","family":"Dickler","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center New York New York"},{"name":"Weill Cornell Medical College New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Peppercorn","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Cancer Center Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee W.","family":"Jones","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center New York New York"},{"name":"Weill Cornell Medical College New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2017.04.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181e0c112"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.27"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.7687"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2013.781673"},{"key":"e_1_2_8_7_1","first-page":"975","article-title":"The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healthy adults","volume":"30","author":"American College of Sports Medicine Position Stand","year":"1998","journal-title":"Med Sci Sports Exerc."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001545"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3181e52e69"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/02701367.1999.10608028"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb01616.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.3.974"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025014509626"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_2_8_17_1","first-page":"129","article-title":"Pain assessment: global use of the Brief Pain Inventory","volume":"23","author":"Cleeland CS","year":"1994","journal-title":"Ann Acad Med Singapore."},{"key":"e_1_2_8_18_1","first-page":"141","article-title":"A simple method to assess exercise behavior in the community","volume":"10","author":"Godin G","year":"1985","journal-title":"Can J Appl Sport Sci."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120996"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31819d18e5"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29899"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.2024"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.1081"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000461"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.9014"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp235"},{"key":"e_1_2_8_27_1","article-title":"Updated systematic review of exercise studies in breast cancer survivors: attention to the principles of exercise training","author":"Neil\u2010Sztramko SE","journal-title":"Br J Sports Med."},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17-0046"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j2998"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.31368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.31368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:15:52Z","timestamp":1760264152000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.31368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,6]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,6,15]]}},"alternative-id":["10.1002\/cncr.31368"],"URL":"https:\/\/doi.org\/10.1002\/cncr.31368","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,6]]},"assertion":[{"value":"2017-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}