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Transplantation is an established option for relapsed FL, but its efficacy in this specific ETF FL population has not been previously evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This study compared autologous hematopoietic stem cell transplantation (auto\u2010HCT) with either matched sibling donor (MSD) or matched unrelated donor (MUD) allogeneic hematopoietic cell transplantation (allo\u2010HCT) as the first transplantation approach for patients with ETF FL (age\u2009\u2265\u200918 years) undergoing auto\u2010HCT or allo\u2010HCT between 2002 and 2014. The primary endpoint was OS. The secondary endpoints were progression\u2010free survival, relapse, and nonrelapse mortality (NRM).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Four hundred forty FL patients had ETF (auto\u2010HCT, 240; MSD hematopoietic stem cell transplantation [HCT], 105; and MUD HCT, 95). With a median follow\u2010up of 69 to 73 months, the adjusted probability of 5\u2010year OS was significantly higher after auto\u2010HCT (70%) or MSD HCT (73%) versus MUD HCT (49%; <jats:italic>P<\/jats:italic>\u2009=\u2009.0008). The 5\u2010year adjusted probability of NRM was significantly lower for auto\u2010HCT (5%) versus MSD (17%) or MUD HCT (33%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). The 5\u2010year adjusted probability of disease relapse was lower with MSD (31%) or MUD HCT (23%) versus auto\u2010HCT (58%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Patients with high\u2010risk FL, as defined by ETF, undergoing auto\u2010HCT for FL have low NRM and a promising 5\u2010year OS rate (70%). MSD HCT has lower relapse rates than auto\u2010HCT but similar OS. <jats:bold><jats:italic>Cancer<\/jats:italic> 2018;124:2541\u201051.<\/jats:bold> \u00a9 <jats:italic>2018 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.31374","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T07:17:31Z","timestamp":1523517451000},"page":"2541-2551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Autologous transplantation versus allogeneic transplantation in patients with follicular lymphoma experiencing early treatment failure"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9893-4949","authenticated-orcid":false,"given":"Sonali M.","family":"Smith","sequence":"first","affiliation":[{"name":"Section of Hematology\/Oncology University of Chicago Chicago 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