{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:01:57Z","timestamp":1790946117840,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T00:00:00Z","timestamp":1525305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,7,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The ultimate goal of chronic myeloid leukemia management in the tyrosine kinase inhibitor (TKI) era for patients who obtain deep molecular responses is maintaining a durable off\u2010treatment response after treatment discontinuation; this situation is called treatment\u2010free remission (TFR). Knowledge accumulated during the last 10 years justifies moving TFR strategies from research to clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Twenty experts from the French Chronic Myeloid Leukemia Study Group (France Intergroupe des Leuc\u00e9mies My\u00e9lo\u00efdes Chroniques), including 17 hematologists, 2 molecular biologists, and 1 cytogeneticist, critically reviewed published data with the goal of developing evidence\u2010based recommendations for TKI discontinuation in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Clinically relevant questions were addressed, including the selection of candidate patients (with known prognostic factors for outcomes taken into account), detailed monitoring procedures during the treatment\u2010free phase, a definition of relapse requiring therapy resumption, and monitoring after treatment reintroduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This work presents consensus statements with the aim of guiding physicians and biologists by means of pragmatic recommendations for safe TKI discontinuation in daily practice. <jats:bold><jats:italic>Cancer<\/jats:italic> 2018;124:2956\u201063.<\/jats:bold> \u00a9 <jats:italic>2018 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.31411","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T19:05:46Z","timestamp":1525374346000},"page":"2956-2963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia: Recommendations for clinical practice from the French Chronic Myeloid Leukemia Study Group"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5379-7461","authenticated-orcid":false,"given":"Delphine","family":"Rea","sequence":"first","affiliation":[{"name":"French Chronic Myeloid Leukemia Study Group, Bergoni\u00e9 Institute Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanti","family":"Ame","sequence":"additional","affiliation":[{"name":"French Chronic Myeloid Leukemia Study Group, Bergoni\u00e9 Institute Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Berger","sequence":"additional","affiliation":[{"name":"French Chronic Myeloid Leukemia Study Group, Bergoni\u00e9 Institute Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Michel","family":"Cayuela","sequence":"additional","affiliation":[{"name":"French Chronic Myeloid Leukemia Study Group, Bergoni\u00e9 Institute Bordeaux 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