{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:29:43Z","timestamp":1784946583948,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:00:00Z","timestamp":1525737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA98543"],"award-info":[{"award-number":["U10CA98543"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The Children's Oncology Group AHOD0431 study evaluated a response\u2010directed treatment paradigm in which minimal initial chemotherapy and low\u2010dose radiation was received only by patients who did not achieve a complete remission, and a chemotherapy\/low\u2010dose radiation salvage regimen was received by those who had a protocol\u2010defined, low\u2010risk recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Patients younger than 21 years who had stage IA or IIA nonbulky disease were eligible. The treatment strategy was evaluated by determining the proportion that received minimal chemotherapy alone, the proportion that had a first or second remission without the receipt of high\u2010dose chemotherapy\/stem cell rescue or higher dose involved\u2010field radiation therapy (&gt;21 grays), and overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In total, 278 patients were eligible. At 4 years, 49.0% had received minimal chemotherapy and no radiation, 88.8% were in remission without receiving high\u2010dose chemotherapy with stem cell rescue or &gt;21 grays of involved\u2010field radiation therapy, and the overall survival rate was 99.6%. Patients who had mixed cellularity histology had a 4\u2010year event\u2010free survival (EFS) rate of 95.2%, which was significantly better than the 75.8% EFS for those who had nodular sclerosis histology (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.008). A red blood cell sedimentation rate \u226420\u2009mm\/hour and a negative fluorodeoxyglucose\u2010positron emission tomography scan after 1 cycle of chemotherapy (PET1) were associated with a favorable EFS outcome. The study was closed early when the receipt of radiation therapy exceeded the predefined monitoring boundary.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      This limited chemotherapy response\u2010based approach was successful in patients who had a negative PET1 result, had MC histology, or had a low red blood cell sedimentation rate. In this treatment paradigm, evaluation of increased chemotherapy intensity or the integration of active new agents is indicated for patients who have nodular sclerosis histology with a high ESR or who have a positive PET1 result.\n                      <jats:bold>\n                        <jats:italic>Cancer<\/jats:italic>\n                        2018.\n                      <\/jats:bold>\n                      \u00a9\n                      <jats:italic>2018 American Cancer Society<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31519","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T12:37:40Z","timestamp":1525783060000},"page":"3210-3219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Results of the AHOD0431 trial of response adapted therapy and a salvage strategy for limited stage, classical Hodgkin lymphoma: A report from the Children's Oncology Group"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6165-5666","authenticated-orcid":false,"given":"Frank G.","family":"Keller","sequence":"first","affiliation":[{"name":"Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta and Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Castellino","sequence":"additional","affiliation":[{"name":"Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta and Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Information Sciences City of Hope, Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglin","family":"Pei","sequence":"additional","affiliation":[{"name":"Statistics and Data Center, Children's Oncology Group University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan D.","family":"Voss","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Children's Hospital, Dana\u2010Farber\/Harvard Cancer Center Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"McCarten","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging Brown University Alpert Medical School Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy L.","family":"Senn","sequence":"additional","affiliation":[{"name":"Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta and Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen B.","family":"Buxton","sequence":"additional","affiliation":[{"name":"Statistics and Data Center, Children's Oncology Group University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizvan","family":"Bush","sequence":"additional","affiliation":[{"name":"Statistics and Data Center, Children's Oncology Group University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis S.","family":"Constine","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy L.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical College of Wisconsin Milwaukee 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