{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:53:36Z","timestamp":1790600016871,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:00:00Z","timestamp":1526256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Israel Science Foundation and the Israel Cancer Research"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,7,15]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Up to half of patients with oral cavity squamous cell carcinoma (OCSCC) have stage I to II disease. When adequate resection is attained, no further treatment is needed; however, re\u2010resection or radiotherapy may be indicated for patients with positive or close margins. This multicenter study evaluated the outcomes and role of adjuvant treatment in patients with stage I to II OCSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Overall survival (OS), disease\u2010specific survival, local\u2010free survival, and disease\u2010free survival rates were calculated with Kaplan\u2010Meier analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of 1257 patients with T1\u20102N0M0 disease, 33 (2.6%) had positive margins, and 205 (16.3%) had close margins. The 5\u2010year OS rate was 80% for patients with clear margins, 52% for patients with close margins, and 63% for patients with positive margins (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). In a multivariate analysis, age, depth of invasion, and margins were independent predictors of outcome. Close margins were associated with a &gt;2\u2010fold increase in the risk of recurrence (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). The multivariate analysis revealed that adjuvant treatment significantly improved the outcomes of patients with close\/positive margins (<jats:italic>P<\/jats:italic>\u2009=\u2009.002 to .03).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Patients with stage I to II OCSCC and positive\/close margins have poor long\u2010term outcomes. For this population, adjuvant treatment may be associated with improved survival. <jats:bold><jats:italic>Cancer<\/jats:italic> 2018;124:2948\u201055.<\/jats:bold> \u00a9 <jats:italic>2018 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.31531","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T09:43:48Z","timestamp":1526291028000},"page":"2948-2955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["The role of adjuvant treatment in early\u2010stage oral cavity squamous cell carcinoma: An international collaborative study"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0493-0243","authenticated-orcid":false,"given":"Eran","family":"Fridman","sequence":"first","affiliation":[{"name":"Rambam Healthcare Campus, Technion\u2013Israel Institute of Technology Haifa Israel"},{"name":"Laboratory for Applied Cancer Research, Technion\u2013Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shorook","family":"Na'ara","sequence":"additional","affiliation":[{"name":"Rambam Healthcare Campus, Technion\u2013Israel Institute of Technology Haifa Israel"},{"name":"Laboratory for Applied Cancer Research, Technion\u2013Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaiprakash","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Tata Memorial Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moran","family":"Amit","sequence":"additional","affiliation":[{"name":"Rambam Healthcare Campus, Technion\u2013Israel Institute of Technology Haifa Israel"},{"name":"Laboratory for Applied Cancer Research, Technion\u2013Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Bachar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Rabin Medical Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Bolzoni","family":"Villaret","sequence":"additional","affiliation":[{"name":"Ear, Nose, and Throat Department University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Brandao","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio R.","family":"Cernea","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Tata Memorial Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Clark","sequence":"additional","affiliation":[{"name":"Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital Sydney New South Wales Australia"},{"name":"Department of Head and Neck Surgery Liverpool Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardalan","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital Sydney New South Wales Australia"},{"name":"Department of Head and Neck Surgery Liverpool Hospital Sydney New South Wales Australia"},{"name":"University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan M.","family":"Fliss","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Tel Aviv Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sashikanth","family":"Jonnalagadda","sequence":"additional","affiliation":[{"name":"Southern Illinois University School of Medicine Springfield Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo F.","family":"Kohler","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, A. C. Camargo Cancer Center S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz P.","family":"Kowalski","sequence":"additional","affiliation":[{"name":"A. C. Camargo Cancer Center S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kreppel","sequence":"additional","affiliation":[{"name":"Department of Oral and Cranio\u2010Maxillo and Facial Plastic Surgery University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Ta","family":"Liao","sequence":"additional","affiliation":[{"name":"Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehal G.","family":"Patel","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Service, Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan S.","family":"Patel","sequence":"additional","affiliation":[{"name":"University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Thomas","family":"Robbins","sequence":"additional","affiliation":[{"name":"Southern Illinois University School of Medicine Carbondale Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatin P.","family":"Shah","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Service, Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Shpitzer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Rabin Medical Center Petach Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Chen","family":"Yen","sequence":"additional","affiliation":[{"name":"Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim E.","family":"Z\u00f6ller","sequence":"additional","affiliation":[{"name":"Department of Oral and Cranio\u2010Maxillo and Facial Plastic Surgery University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziv","family":"Gil","sequence":"additional","affiliation":[{"name":"Rambam Healthcare Campus, Technion\u2013Israel Institute of Technology Haifa Israel"},{"name":"Laboratory for Applied Cancer Research, Technion\u2013Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the International Consortium for Outcome Research in Head and Neck Cancer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.05.017"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1539"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20279"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24320"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.4238"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.0548"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2002.0313"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28357"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.1351"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wjorl.2016.02.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80555-0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0101"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.5.536"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.570"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23871"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24631"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.9866"},{"key":"e_1_2_8_22_1","volume-title":"R: A Language and Environment for Statistic Computing","author":"R Core Team","year":"2017"},{"key":"e_1_2_8_23_1","unstructured":"GrayB.cmprsk: Subdistribution Analysis of Competing Risks. 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