{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:45:29Z","timestamp":1790455529286,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T00:00:00Z","timestamp":1534464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013362","name":"Swiss Cancer Research","doi-asserted-by":"crossref","award":["KLS-3412-02-2014"],"award-info":[{"award-number":["KLS-3412-02-2014"]}],"id":[{"id":"10.13039\/501100013362","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013362","name":"Swiss Cancer Research","doi-asserted-by":"crossref","award":["KLS-3644-02-2015"],"award-info":[{"award-number":["KLS-3644-02-2015"]}],"id":[{"id":"10.13039\/501100013362","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013362","name":"Swiss Cancer Research","doi-asserted-by":"crossref","award":["KLS-3886-02-2016"],"award-info":[{"award-number":["KLS-3886-02-2016"]}],"id":[{"id":"10.13039\/501100013362","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Foundation Force, CHUV (Lausanne, Switzerland)"},{"name":"Swiss Childhood Cancer"},{"name":"Swiss Pediatric Oncology Group"},{"name":"Federal Office of Public Health"},{"name":"National Institute of Cancer Epidemiology and Registration"},{"name":"Foundation Force"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Glucocorticoids can lead to weight gain during cancer treatment, but to the authors' knowledge, little is known regarding their long\u2010term effects in childhood cancer survivors (CCS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>As part of the Swiss Childhood Cancer Survivor Study, the authors sent a questionnaire to CCS aged &lt;21 years at diagnosis who were residing in Switzerland, had survived \u22655 years, and were aged 15 to 45 years at the time of the survey. Cumulative doses of glucocorticoids were assessed from medical records and study protocols and body mass index was calculated from self\u2010reported height and weight at the time of the survey. The authors compared the prevalence of overweight between CCS, their siblings, and the general population (Swiss Health Survey [SHS]) and investigated the association between overweight and treatment\u2010related risk factors using multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The study included 1936 CCS, 546 siblings, and 9591 SHS participants. The median age of the CCS at the time of the survey was 24 years (interquartile range, 20\u201031 years) and the median time since diagnosis was 17 years (interquartile range, 12\u201022 years). At the time of the survey, approximately 26% of CCS were overweight, a percentage that was comparable to that among siblings (24%) and the SHS participants (25%). The prevalence of overweight was 24% in CCS treated with glucocorticoids only (686 CCS), 37% in those treated with cranial radiotherapy (CRT) (127 CCS), and 49% in those who received treatment with both glucocorticoids and CRT (101 CCS) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). The authors found no evidence of a dose\u2010response relationship between cumulative glucocorticoid doses and overweight and no evidence that CRT modified the effect of the cumulative glucocorticoid dose on overweight.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The results of the current study suggest that glucocorticoids used for the treatment of childhood cancer are not associated with long\u2010term risk of overweight.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31599","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T18:32:47Z","timestamp":1534530767000},"page":"3576-3585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["No evidence of overweight in long\u2010term survivors of childhood cancer after glucocorticoid treatment"],"prefix":"10.1002","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0037-4817","authenticated-orcid":false,"given":"Fabi\u00ebn N.","family":"Belle","sequence":"first","affiliation":[{"name":"Swiss Childhood Cancer Registry, Institute of Social and Preventive Medicine University of Bern Bern Switzerland"},{"name":"Division of Chronic Diseases, Institute of Social and Preventive Medicine Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0856-3436","authenticated-orcid":false,"given":"Rahel","family":"Kasteler","sequence":"additional","affiliation":[{"name":"Swiss Childhood Cancer Registry, Institute of Social and Preventive Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Schindera","sequence":"additional","affiliation":[{"name":"Swiss Childhood Cancer Registry, Institute of Social and Preventive Medicine University of Bern Bern Switzerland"},{"name":"Department of Pediatrics, Inselspital, Bern University Hospital University of Bern Bern Switzerland"},{"name":"Department of Hematology, University Children's Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murielle","family":"Bochud","sequence":"additional","affiliation":[{"name":"Division of Chronic Diseases, Institute of Social and Preventive Medicine Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland A.","family":"Ammann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Inselspital, Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas X.","family":"von der Weid","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Children's Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8957-2002","authenticated-orcid":false,"given":"Claudia E.","family":"Kuehni","sequence":"additional","affiliation":[{"name":"Swiss Childhood Cancer Registry, Institute of Social and Preventive Medicine University of Bern Bern Switzerland"},{"name":"Department of Pediatrics, Inselspital, Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Swiss Pediatric Oncology Group (SPOG)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08192.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0282-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158225"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2178"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00038-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70114-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-38-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3332"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23050"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-911X(200008)35:2<91::AID-MPO1>3.0.CO;2-G"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29153"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2718-5"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181ece2bb"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-008-0531-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21496"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.1.70"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0622"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199507000-00015"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr142"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.4414\/smw.2007.11875","article-title":"The Swiss Childhood Cancer Registry: rationale, organisation and results for the years 2001\u20102005","volume":"137","author":"Michel G","year":"2007","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21129"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1316"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21335"},{"key":"e_1_2_8_25_1","volume-title":"The Swiss Health Survey 2012 in brief. Concept, method, implementation","author":"Swiss Confederation Federal Statistical Office FSO","year":"2013"},{"key":"e_1_2_8_26_1","volume-title":"Final report on the 2000 census","author":"Germann U","year":"2005"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqx006"},{"key":"e_1_2_8_28_1","first-page":"51S","article-title":"Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report","volume":"6","author":"National Institutes of Health","year":"1998","journal-title":"Obesity Res"},{"key":"e_1_2_8_29_1","first-page":"22","article-title":"New growth curves for Switzerland","author":"Braegger C","year":"2011","journal-title":"Paediatrica"},{"key":"e_1_2_8_30_1","unstructured":"World Health Organization.International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD\u201010).http:\/\/apps.who.int\/classifications\/icd10\/browse\/2010\/en#\/P05-P08. Accessed January 3 2018."},{"key":"e_1_2_8_31_1","unstructured":"US Department of Health and Human Services; Food and Drug Administration; Center for Drug Evaluation and Research (CDER).Guidance for industry: estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers.https:\/\/www.fda.gov\/downloads\/Drugs\/..\/Guidances\/UCM078932.pdf. Accessed June 9 2017."},{"key":"e_1_2_8_32_1","first-page":"1459","volume-title":"The Pharmacological Basis of Therapeutics","author":"Haynes RC","year":"1985"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.0457"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24960"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12754"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.02.1241"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.31599","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.31599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:45:15Z","timestamp":1761871515000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.31599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,17]]},"references-count":35,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/cncr.31599"],"URL":"https:\/\/doi.org\/10.1002\/cncr.31599","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,17]]},"assertion":[{"value":"2018-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}