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Therefore, we evaluated associations between weight change and breast cancer risk in postmenopausal women in the Women\u2019s Health Initiative Observational Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Postmenopausal women (n = 61,335) who had no prior breast cancer and a normal mammogram had body weight and height measured and body mass index (BMI) calculated at baseline and year 3. Weight change at year 3 was categorized as stable (&lt;5%), loss (\u22655%), or gain (\u22655%) with further assessment of weight loss intentionality by self\u2010report. Multivariable Cox proportional hazard regression models were used to evaluate relationships between weight change and subsequent breast cancer incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a mean follow\u2010up of 11.4 years with 3061 incident breast cancers, women with weight loss (n = 8175) had a significantly lower risk of breast cancer compared with women whose weight remained stable (n = 41,139) (hazard ratio [HR], 0.88; 95% confidence interval [CI], 0.78\u20100.98;\n                      <jats:italic>P<\/jats:italic>\n                      = .02) with no interaction by BMI. Adjustment for mammography did not alter findings (HR, 0.88; 95% CI, 0.78\u20100.99) with no significant difference by weight loss intentionality. Weight gain (\u22655%) (n = 12,021) was not associated with breast cancer risk (HR, 1.02; 95% CI, 0.93\u20101.11) but was associated with higher triple\u2010negative breast cancer incidence (HR, 1.54; 95% CI, 1.16\u20102.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Postmenopausal women who lose weight have lower breast cancer risk than those with stable weight. These findings suggest that postmenopausal women who lose weight may reduce their breast cancer risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31687","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T03:01:26Z","timestamp":1538967686000},"page":"205-212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Weight loss and breast cancer incidence in postmenopausal women"],"prefix":"10.1002","volume":"125","author":[{"given":"Rowan T.","family":"Chlebowski","sequence":"first","affiliation":[{"name":"Department of Medical Oncology and Therapeutics Research City of Hope National Medical Center Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhua","family":"Luo","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics Indiana University Bloomington Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garnet L.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Barrington","sequence":"additional","affiliation":[{"name":"Psychosocial and Community Health University of Washington Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerryn","family":"Reding","sequence":"additional","affiliation":[{"name":"Biobehavioral Nursing and Health Informatics University of Washington Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Simon","sequence":"additional","affiliation":[{"name":"Clinical Arrangements Karmanos Cancer Institute Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnn E.","family":"Manson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Brigham and Women\u2019s Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Rohan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Population Health Albert Einstein College of Medicine Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Wactawski\u2010Wende","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Environmental Health State University of New York at Buffalo Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Population Health Stony Brook University School of Medicine Stony Brook New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Strickler","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Population Health Albert Einstein College of Medicine Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Mosaver\u2010Rahmani","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Population Health Albert Einstein College of Medicine Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo L.","family":"Freudenheim","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Environmental Health State University of New York at Buffalo Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazmus","family":"Saquib","sequence":"additional","affiliation":[{"name":"Department of Research Sulaimaon Al Rajhi College School of Medicine Al Bukayri ah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia L.","family":"Stefanick","sequence":"additional","affiliation":[{"name":"Department of Medicine Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.4.1128"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-0990-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60460-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1606602"},{"key":"e_1_2_10_6_1","first-page":"611","article-title":"obesity and postmenopausal invasive breast cancer risk. 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