{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:39:14Z","timestamp":1761896354723,"version":"build-2065373602"},"reference-count":34,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T00:00:00Z","timestamp":1539129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["K12HS023009"],"award-info":[{"award-number":["K12HS023009"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To the authors\u2019 knowledge, there is limited information regarding the long\u2010term risk of congestive heart failure (CHF) among patients with follicular lymphoma, a prevalent non\u2010Hodgkin lymphoma diagnosis among those aged &gt;65 years, especially within the context of therapeutic exposures and preexisting comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using Surveillance, Epidemiology, and End Results\u2013Medicare data from 1999 through 2013, the authors identified 6109 patients with follicular lymphoma who were diagnosed at age \u226566 years between January 1, 2000 and December 31, 2011, and a frequency\u2010matched Medicare noncancer sample. Subdistribution hazards models assessed risks associated with new\u2010onset CHF through December 31, 2013. Propensity score\u2013matched models examined CHF risk in patients receiving anthracyclines when compared with matched noncancer controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>When compared with matched controls, patients with follicular lymphoma receiving anthracyclines at ages 66 to 75 years had a 1.7\u2010fold (95% confidence interval, 1.4\u2010fold to 2.1\u2010fold) higher risk of new\u2010onset CHF; patients diagnosed at age &gt;75 years did not differ from noncancer controls with regard to CHF risk. Preexisting hypertension was associated with a 1.7\u2010fold and 1.35\u2010fold, respectively, increased hazard of CHF for each age group, independent of anthracycline exposure. Preexisting diabetes was associated with 1.5\u2010fold increased hazard of CHF only in those patients aged 66 to 75 years. Patients with new\u2010onset CHF had a 18% lower 10\u2010year survival compared with those without CHF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with follicular lymphoma who were exposed to anthracyclines between the ages of 66 years and 75 years were found to be at an increased risk of new\u2010onset CHF; preexisting hypertension and diabetes appeared to increase this risk. The findings of the current study support and inform the risk\u2010based follow\u2010up of vulnerable populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31695","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T15:12:01Z","timestamp":1539184321000},"page":"4221-4230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Congestive heart failure in older adults diagnosed with follicular lymphoma: A population\u2010based study"],"prefix":"10.1002","volume":"124","author":[{"given":"Kelly M.","family":"Kenzik","sequence":"first","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham  Birmingham Alabama"},{"name":"Division of Hematology and Oncology University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amitkumar","family":"Mehta","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua S.","family":"Richman","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith","family":"Kilgore","sequence":"additional","affiliation":[{"name":"Department of Health Care Organization and Policy University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smita","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham  Birmingham Alabama"},{"name":"Division of Pediatric Hematology Oncology University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"National Cancer Institute National Institutes of Health.Adult Non\u2010Hodgkin Lymphoma Treatment (PDQ\u00ae)\u2013Health Professional Version.https:\/\/www.cancer.gov\/types\/lymphoma\/hp\/adult-nhl-treatment-pdq#link\/_552_toc. 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