{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:00:15Z","timestamp":1785495615666,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The treatment of patients with Hodgkin lymphoma (HL) who develop disease progression after undergoing allogeneic stem cell transplantation (allo\u2010SCT) remains challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The authors assessed outcomes in 184 adult patients with HL who developed disease recurrence or progression after a matched related or unrelated allo\u2010SCT at European Society for Blood and Marrow Transplantation\u2013participating centers between 2010 and 2014.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty patients who received brentuximab vedotin (BV) salvage therapy were compared with 104 patients who did not. Patients in the BV group were younger (median age of 30 years vs 34 years) and were more likely to receive pretransplant BV (65% vs 46%) or posttransplant donor lymphocyte infusion (66% vs 33%). The 2 groups otherwise were comparable. Patients in the BV group received a median of 6 doses of posttransplant BV, resulting in a complete remission rate of 29%, a partial response rate of 45%, and a stable disease rate of 26%. Response to BV after allo\u2010SCT did not appear to be affected by receipt of pretransplant BV. Despite a longer median follow\u2010up for surviving patients in the BV group (33 months vs 23 months;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.001), approximately 34% of the original BV cohort were alive and in CR at the time of last follow\u2010up versus 18% in the group that did not receive BV (\n                      <jats:italic>P<\/jats:italic>\n                      =.003). The use of BV before donor lymphocyte infusion was found to be associated with the highest probability of being alive and in CR (40%) at the time of last follow\u2010up. Salvage BV appeared to have no effect on chronic graft\u2010versus\u2010host disease or 1\u2010year overall survival from the time of disease recurrence after allo\u2010SCT (76% vs 67%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BV is a safe and effective salvage therapy for patients with HL who develop disease recurrence or progression after undergoing allo\u2010SCT, even after prior exposure to BV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31755","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T12:02:29Z","timestamp":1540296149000},"page":"90-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Brentuximab vedotin for recurrent Hodgkin lymphoma after allogeneic hematopoietic stem cell transplantation: A report from the EBMT Lymphoma Working Party"],"prefix":"10.1002","volume":"125","author":[{"given":"Ali","family":"Bazarbachi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine American University of Beirut Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Boumendil","sequence":"additional","affiliation":[{"name":"European Society for Blood and Marrow Transplantation Lymphoma Working Party Paris Office Saint\u2010Antoine Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Finel","sequence":"additional","affiliation":[{"name":"European Society for Blood and Marrow Transplantation Lymphoma Working Party Paris Office Saint\u2010Antoine Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Mohty","sequence":"additional","affiliation":[{"name":"Department of Hematology and Cell Therapy Saint Antoine Hospital, Sorbonne University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Castagna","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Humanitas Clinic Institute Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Department of Hematology Paoli Calmettes Institute Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl S.","family":"Peggs","sequence":"additional","affiliation":[{"name":"Department of Hematology University College London Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Afanasyev","sequence":"additional","affiliation":[{"name":"Department of Hematology First State Pavlov Medical University of St. Petersburg St. Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Diez\u2010Martin","sequence":"additional","affiliation":[{"name":"Department of Hematology Gregorio Maranon Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Corradini","sequence":"additional","affiliation":[{"name":"Department of Hematology IRCCS National Cancer Institute, University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Michonneau","sequence":"additional","affiliation":[{"name":"Department of Hematology and Stem Cell Transplant St. Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology University Hospital Bristol Bristol United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Guti\u00e9rrez Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Hospital Clinic Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bonifazi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Hematology Department \u201cSeragnoli,\u201d S. Orsola\u2010Malpighi University Hospital Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Yakoub\u2010Agha","sequence":"additional","affiliation":[{"name":"Department of Hematology, Lille Regional Hospital Center LIRIC INSERM U995, Lille University Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafer","family":"G\u00fclbas","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology and Bone Marrow Transplantation Anadolu Medical Center Hospital Kocaeli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Bloor","sequence":"additional","affiliation":[{"name":"Department of Hematology and Stem Cell Transplant Christie NHS Foundation Trust Manchester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Delage","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology Lapeyronie 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