{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:00:19Z","timestamp":1793070019089,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:00:00Z","timestamp":1539820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,1,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Limited data exist on the safety of using anti\u2013human epidermal growth factor receptor 2 (HER2) targeted agents during pregnancy. To date, only retrospective studies have assessed the prognosis of patients with a pregnancy after prior early breast cancer, with no data in HER2\u2010positive patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Neoadjuvant Lapatinib and\/or Trastuzumab Treatment Optimization (NeoALTTO) trial and the Adjuvant Lapatinib and\/or Trastuzumab Treatment Optimization (ALTTO) trial were randomized phase 3 trials for patients with HER2\u2010positive early breast cancer. In both trials, pregnancy information was prospectively collected. Pregnancy outcomes were compared between patients unintentionally exposed to trastuzumab and\/or lapatinib during gestation (the exposed group) and those who became pregnant after trastuzumab and\/or lapatinib completion (the unexposed group). In the ALTTO trial, disease\u2010free survival (DFS) was compared between pregnant patients and those aged 40 years or younger without a subsequent pregnancy via an extended Cox model with time\u2010varying covariates to account for a guarantee\u2010time bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety\u2010two patients (12 in the exposed group and 80 in the unexposed group) had a pregnancy: 7 in the NeoALTTO trial and 85 in the ALTTO trial. Seven patients (58.3%) in the exposed group and 10 patients (12.5%) in the unexposed group opted for an induced abortion; in the unexposed group, 10 patients (12.5%) had a spontaneous abortion. No pregnancy\/delivery complications were reported for the remaining cases, who successfully completed their pregnancy, with the exception of 1 fetus with trisomy 21 (Down syndrome). No significant difference in DFS (adjusted hazard ratio, 1.12; 95% confidence interval, 0.52\u20102.42) was observed between young patients with a pregnancy (n = 85) and young patients without a pregnancy (n = 1307).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For patients with HER2\u2010positive early breast cancer, having a pregnancy after treatment completion appears to be safe without compromising fetal outcome or maternal prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31784","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T08:54:32Z","timestamp":1539852872000},"page":"307-316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Pregnancies during and after trastuzumab and\/or lapatinib in patients with human epidermal growth factor receptor 2\u2013positive early breast cancer: Analysis from the NeoALTTO (BIG 1\u201006) and ALTTO (BIG 2\u201006) trials"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1797-5296","authenticated-orcid":false,"given":"Matteo","family":"Lambertini","sequence":"first","affiliation":[{"name":"Department of Medicine Institut Jules Bordet and Universit\u00e9 Libre de Bruxelles (ULB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Martel","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology, CISSS Mont\u00e9r\u00e9gie\u2010Centre\/H\u00f4pital Charles\u2013Le Moyne Universit\u00e9 de Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Campbell","sequence":"additional","affiliation":[{"name":"Frontier Science Kingussie United 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