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There is substantial variation in the severity and persistence of cancer\u2010related fatigue that may be driven by individual differences in host factors, including characteristics that predate the cancer experience as well as responses to cancer and its treatment. This review examines biobehavioral risk factors linked to fatigue and the mechanisms through which they influence fatigue across the cancer continuum, with a focus on neuro\u2010immune processes. Among psychosocial risk factors, childhood adversity is a strong and consistent predictor of cancer\u2010related fatigue; other risk factors include history of depression, catastrophizing, lack of physical activity, and sleep disturbance, with compelling preliminary evidence for loneliness and trait anxiety. Among biologic systems, initial work suggests that alterations in immune, neuroendocrine, and neural processes are associated with fatigue. The identification of key risk factors and underlying mechanisms is critical for the development and deployment of targeted interventions to reduce the burden of fatigue in the growing population of cancer survivors. Given the multidimensional nature of fatigue, interventions that influence multiple systems may be most effective.<\/jats:p>","DOI":"10.1002\/cncr.31790","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T12:03:20Z","timestamp":1546430600000},"page":"353-364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":203,"title":["The role of neuro\u2010immune interactions in cancer\u2010related fatigue: Biobehavioral risk factors and mechanisms"],"prefix":"10.1002","volume":"125","author":[{"given":"Julienne E.","family":"Bower","sequence":"first","affiliation":[{"name":"Department of Psychology, Department of Psychiatry and Biobehavioral Sciences, Cousins Center for Psychoneuroimmunology, and Jonsson Comprehensive Cancer Center University of California Los Angeles 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