{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:20:53Z","timestamp":1790360453406,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T00:00:00Z","timestamp":1545004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Survivors of Hodgkin lymphoma (HL) in childhood have an increased risk of subsequent malignant neoplasms (SMNs). Herein, the authors extended the follow\u2010up of a previously reported Late Effects Study Group cohort and identified patients at highest risk for SMNs to create evidence for risk\u2010based screening recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The standardized incidence ratio was calculated using rates from the Surveillance, Epidemiology, and End Results program as a reference. The risk of SMN was estimated using proportional subdistribution hazards regression. The cohort included 1136 patients who were diagnosed with HL before age 17 years between 1955 and 1986. The median length of follow\u2010up was 26.6 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 162 patients, a total of 196 solid SMNs (sSMNs) were identified. Compared with the general population, the cohort was found to be at a 14\u2010fold increased risk of developing an sSMN (95% confidence interval, 12.0\u2010fold to 16.3\u2010fold). The cumulative incidence of any sSMN was 26.4% at 40 years after a diagnosis of HL. Risk factors for breast cancer among females were an HL diagnosis between ages 10 years and 16 years and receipt of chest radiotherapy. Males treated with chest radiotherapy at age &lt;10 years were found to be at highest risk of developing lung cancer. Survivors of HL who were treated with abdominal\/pelvic radiotherapy and high\u2010dose alkylating agents were found to be at highest risk of developing colorectal cancer and females exposed to neck radiotherapy at age &lt;10 years were at highest risk of thyroid cancer. By age 50 years, the cumulative incidence of breast, lung, colorectal, and thyroid cancer was 45.3%, 4.2%, 9.5%, and 17.3%, respectively, among those at highest risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Survivors of childhood HL remain at an increased risk of developing sSMNs. In the current study, subgroups of survivors of HL at highest risk of specific sSMNs were identified, and evidence for screening provided.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31807","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T03:10:51Z","timestamp":1545016251000},"page":"1373-1383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Risk of solid subsequent malignant neoplasms after childhood Hodgkin lymphoma\u2014Identification of high\u2010risk populations to guide surveillance: A report from the Late Effects Study Group"],"prefix":"10.1002","volume":"125","author":[{"given":"Anna S.","family":"Holmqvist","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund University Lund Sweden"},{"name":"Pediatric Oncology and Hematology Skane University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Berano Teh","sequence":"additional","affiliation":[{"name":"Department of Population Sciences City of Hope Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canlan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Population Sciences City of Hope Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian M.","family":"Birch","sequence":"additional","affiliation":[{"name":"Pediatric and Familial Cancer Research Group, Cancer Research UK Royal Manchester Children\u2019s Hospital Manchester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cor","family":"van den Bos","sequence":"additional","affiliation":[{"name":"Emma Children\u2019s Hospital, Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa R.","family":"Diller","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley","family":"Dilley","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Stem Cell Transplantation, Department of Pediatrics Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Ginsberg","sequence":"additional","affiliation":[{"name":"Center for Childhood Cancer Research, Department of Pediatrics University of Pennsylvania School of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura T.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Ohio State University College of Medicine Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajaram","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Cincinnati Children\u2019s Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Nathan","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Neglia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Minnesota Medical School Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Terenziani","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Unit IRCCS Foundation National Cancer Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tishler","sequence":"additional","affiliation":[{"name":"Children\u2019s Center for Cancer and Blood Diseases Children\u2019s Hospital Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna T.","family":"Meadows","sequence":"additional","affiliation":[{"name":"The Children\u2019s Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie L.","family":"Robison","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children\u2019s Research Hospital Memphis 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