{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:57:32Z","timestamp":1789012652145,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R25CA116339-07"],"award-info":[{"award-number":["5R25CA116339-07"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011485","name":"North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","award":["UL1TR001111\u201002 NIH"],"award-info":[{"award-number":["UL1TR001111\u201002 NIH"]}],"id":[{"id":"10.13039\/100011485","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As the US population ages and non\u2010Hodgkin lymphoma (NHL)\u2013specific mortality declines, deaths from causes other than NHL will become increasingly important in treatment decision making for older patients with NHL. The objective of the current study was to describe how the 5\u2010year cumulative incidence of NHL\u2010specific and other\u2010cause mortality varies by subtype, age, comorbidity level, and time since diagnosis in older patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the Surveillance, Epidemiology, and End Results cancer registry data linked to Medicare claims, patients aged \u226566 years were identified at the time of diagnosis with a first, primary NHL diagnosis from 2004 through 2013. Death certificate data and Fine\u2010Gray competing risks models were used to estimate the 5\u2010year cumulative incidence of NHL\u2010specific and other\u2010cause mortality by NHL subtype, age, and comorbidity level. Estimates were displayed over time using stacked cumulative incidence curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 30,666 patients with NHL, 32% died of NHL and 13% died of other causes within 5 years of diagnosis. The cumulative incidence of other\u2010cause mortality increased with age and comorbidity level for all subtypes. Among patients with aggressive NHL subtypes, NHL\u2010specific mortality exceeded other\u2010cause mortality across all age groups, comorbidity levels, and number of years after diagnosis. For patients with indolent NHL subtypes, other\u2010cause mortality was similar to or exceeded NHL\u2010specific mortality, especially among older patients with severe comorbidity or with the indolent marginal zone, lymphoplasmacytic, and mycosis fungoides subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings of the current study suggest that mortality from causes other than NHL are important for patients of an older age, with a higher comorbidity level, and with indolent disease. Evidence from the current study can guide the development of tools for estimating individual prognosis that inform treatment discussions in patients with NHL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31821","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T15:29:37Z","timestamp":1544542177000},"page":"1101-1112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cause\u2010specific mortality among Medicare beneficiaries with newly diagnosed non\u2010Hodgkin lymphoma subtypes"],"prefix":"10.1002","volume":"125","author":[{"given":"Laura L.","family":"Hester","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill Chapel Hill North Carolina"},{"name":"Janssen Research &amp; Development LLC Titusville New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven I.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina"},{"name":"Division of Hematology and Oncology Levine Cancer Institute Charlotte North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Wood","sequence":"additional","affiliation":[{"name":"Leukemia, Lymphoma, and Myeloma Program, School of Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Til","family":"St\u00fcrmer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Alan","family":"Brookhart","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,11]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"American Cancer Society.Cancer Facts & Figures 2018.Atlanta GA:American Cancer Society 2018.https:\/\/www.cancer.org\/research\/cancer-facts-statistics\/all-cancer-facts-figures\/cancer-facts-figures-2018.html. 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