{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T06:10:47Z","timestamp":1764828647882,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA16672","CA016672"],"award-info":[{"award-number":["CA16672","CA016672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clips are often placed to mark axillary nodes with biopsy\u2010confirmed metastases in patients with breast cancer. The evaluation of clipped nodes after chemotherapy can identify patients who have eradication of nodal disease. The goal of this study was to determine whether preoperative fine\u2010needle aspiration (FNA) of clipped nodes after neoadjuvant chemotherapy (NAC) could predict the presence of residual disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective registry study enrolled 50 patients with a clip placed to mark nodes with biopsy\u2010confirmed metastases who had completed NAC. Participants underwent FNA of the clipped node before seed\u2010localized lymph node excision. FNA pathology was compared with surgical pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 36 patients (72%) with residual disease on surgical pathology: 3 (8%) had a nondiagnostic aspirate, carcinoma was seen in 14 (39%), and 19 (53%) had a false\u2010negative result. The sensitivity of FNA was 42.4%, its specificity was 100%, and its negative predictive value was 40.6%. In a univariate analysis, the odds of a true\u2010positive result increased significantly with the mean initial size of the clipped node (odds ratio [OR], 4.3;\n                      <jats:italic>P<\/jats:italic>\n                      = .004) and the size of the metastatic focus after NAC (OR, 1.3;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.003), whereas normalization of nodes after chemotherapy (OR, 0.1) and a lack of response on ultrasound (OR, 0.11) were associated with a false\u2010negative result (\n                      <jats:italic>P<\/jats:italic>\n                      = .01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FNA of marked nodes after chemotherapy has a high false\u2010negative rate. This highlights the need for surgical staging of the axilla after NAC to assess the response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31825","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T17:55:15Z","timestamp":1540490115000},"page":"365-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Feasibility of fine\u2010needle aspiration for assessing responses to chemotherapy in metastatic nodes marked with clips in breast cancer: A prospective registry study"],"prefix":"10.1002","volume":"125","author":[{"given":"Abigail S.","family":"Caudle","sequence":"first","affiliation":[{"name":"Department of Breast Surgical Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry M.","family":"Kuerer","sequence":"additional","affiliation":[{"name":"Department of Breast Surgical Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savitri","family":"Krishnamurthy","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungmin","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian P.","family":"Hobbs","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Foundation Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junsheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Mittendorf","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Texas MD Anderson Cancer Center Houston Texas"},{"name":"Dana\u2010Farber\/Brigham and Women\u2019s Cancer Center Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley C.","family":"Washington","sequence":"additional","affiliation":[{"name":"Department of Breast Surgical Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah M.","family":"DeSnyder","sequence":"additional","affiliation":[{"name":"Department of Breast Surgical Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalliah M.","family":"Black","sequence":"additional","affiliation":[{"name":"Department of Breast Surgical Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly K.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Department of Breast Surgical Oncology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei T.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10786"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2460"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23344"},{"key":"e_1_2_8_5_1","first-page":"169","article-title":"Clinical evaluation of axillary lymph nodes compared to surgical and pathological findings","volume":"12","author":"Sacre R","year":"1986","journal-title":"Eur J Surg Oncol"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-0919-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010-0373"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002373"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25152"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.278932"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001375"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.0094"},{"key":"e_1_2_8_13_1","unstructured":"National Comprehensive Cancer Network.Clinical practice guidelines in oncology: breast version 2.2017 BINV\u201011.https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/breast.pdf. 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