{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:37:35Z","timestamp":1790235455722,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011105","name":"National University Cancer Institute, Singapore","doi-asserted-by":"publisher","award":["P30 CA16042"],"award-info":[{"award-number":["P30 CA16042"]}],"id":[{"id":"10.13039\/501100011105","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fatigue is one of the most common and disabling side effects of cancer and its treatment. Although research typically has focused on fatigue that occurs during and after treatment, patients may experience fatigue even before treatment onset. The current study was designed to identify biobehavioral risk factors associated with fatigue before adjuvant therapy in women with early\u2010stage breast cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with stage 0 to stage IIIA breast cancer (270 women) were recruited before the onset of adjuvant or neoadjuvant therapy with radiotherapy, chemotherapy, and\/or endocrine therapy. Host factors that may influence fatigue were identified from an empirically based, biobehavioral model and assessed using self\u2010report questionnaires, medical record review, and blood collection (for genetic data). Fatigue was assessed by questionnaire. Linear regression analyses were used to evaluate the association between host factors and dimensions of fatigue, with general fatigue as the primary dimension of interest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fatigue was elevated at the pretreatment assessment compared with published controls. Bivariate analyses identified demographic, cancer\u2010related, and biobehavioral correlates of fatigue. In the multivariable model, predictors of general fatigue included younger age, lower educational level, lower cancer stage, and history of childhood maltreatment (all\n                      <jats:italic>P<\/jats:italic>\n                      values &lt;.05), with the full model accounting for approximately 18.4% of the variance in fatigue. Secondary analyses identified common and specific predictors of emotional, mental, and physical dimensions of fatigue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among women who have not yet initiated treatment of breast cancer, demographic and psychosocial factors are associated with elevated fatigue and could be used to identify at\u2010risk patients for early intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31827","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T11:06:49Z","timestamp":1545131209000},"page":"633-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Testing a biobehavioral model of fatigue before adjuvant therapy in women with breast cancer"],"prefix":"10.1002","volume":"125","author":[{"given":"Julienne E.","family":"Bower","sequence":"first","affiliation":[{"name":"Department of Psychology University of California at Los Angeles Los Angeles California"},{"name":"Department of Psychiatry and Biobehavioral Sciences University of California at Los Angeles Los Angeles California"},{"name":"Norman Cousins Center for Psychoneuroimmunology University of California at Los Angeles Los Angeles California"},{"name":"Jonsson Comprehensive Cancer Center University of California at Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Asher","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center Samuel Oschin Comprehensive Cancer Institute Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Garet","sequence":"additional","affiliation":[{"name":"Norman Cousins Center for Psychoneuroimmunology University of California at Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Petersen","sequence":"additional","affiliation":[{"name":"Jonsson Comprehensive Cancer Center University of California at Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Ganz","sequence":"additional","affiliation":[{"name":"Jonsson Comprehensive Cancer Center University of California at Los Angeles Los Angeles California"},{"name":"School of Medicine University of California at Los Angeles Los Angeles California"},{"name":"School of Public Health University of California at Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Irwin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences University of California at Los Angeles Los Angeles California"},{"name":"Norman Cousins Center for Psychoneuroimmunology University of California at Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve W.","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences University of California at Los Angeles Los Angeles California"},{"name":"Norman Cousins Center for Psychoneuroimmunology University of California at Los Angeles Los Angeles California"},{"name":"Department of Medicine University of California at Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara A.","family":"Hurvitz","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California at Los Angeles Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Crespi","sequence":"additional","affiliation":[{"name":"Jonsson 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