{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:32:11Z","timestamp":1791894731827,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006399","name":"Spectrum Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of autologous stem cell transplantation (ASCT) in the first complete remission (CR1) of peripheral T\u2010cell lymphomas (PTCLs) is not well defined. This study analyzed the impact of ASCT on the clinical outcomes of patients with newly diagnosed PTCL in CR1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with newly diagnosed, histologically confirmed, aggressive PTCL were prospectively enrolled into the Comprehensive Oncology Measures for Peripheral T\u2010Cell Lymphoma Treatment (COMPLETE) study, and those in CR1 were included in this analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two hundred thirteen patients with PTCL achieved CR1, and 119 patients with nodal PTCL, defined as anaplastic lymphoma kinase\u2013negative anaplastic large cell lymphoma, angioimmunoblastic T\u2010cell lymphoma (AITL), or PTCL not otherwise specified, were identified. Eighty\u2010three patients did not undergo ASCT, whereas 36 underwent consolidative ASCT in CR1. At the median follow\u2010up of 2.8 years, the median overall survival was not reached for the entire cohort of patients who underwent ASCT, whereas it was 57.6 months for those not receiving ASCT (\n                      <jats:italic>P<\/jats:italic>\n                      = .06). ASCT was associated with superior survival for patients with advanced\u2010stage disease or intermediate\u2010to\u2010high International Prognostic Index scores. ASCT significantly improved overall and progression\u2010free survival for patients with AITL but not for patients with other PTCL subtypes. In a multivariable analysis, ASCT was independently associated with improved survival (hazard ratio, 0.37; 95% confidence interval, 0.15\u20100.89).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first large prospective cohort study directly comparing the survival outcomes of patients with nodal PTCL in CR1 with or without consolidative ASCT. ASCT may provide a benefit in specific clinical scenarios, but the broader applicability of this strategy should be determined in prospective, randomized trials. These results provide a platform for designing future studies of previously untreated PTCL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31861","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T18:56:56Z","timestamp":1548788216000},"page":"1507-1517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":141,"title":["The role of autologous stem cell transplantation in patients with nodal peripheral T\u2010cell lymphomas in first complete remission: Report from COMPLETE, a prospective, multicenter cohort study"],"prefix":"10.1002","volume":"125","author":[{"given":"Steven I.","family":"Park","sequence":"first","affiliation":[{"name":"Levine Cancer Institute  Charlotte North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Horwitz","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine M.","family":"Foss","sequence":"additional","affiliation":[{"name":"Yale University  New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C.","family":"Pinter\u2010Brown","sequence":"additional","affiliation":[{"name":"University of California Irvine  Irvine California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth R.","family":"Carson","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven T.","family":"Rosen","sequence":"additional","affiliation":[{"name":"City of Hope  Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Pro","sequence":"additional","affiliation":[{"name":"Robert H. Lurie Comprehensive Cancer Center Northwestern University  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Hsi","sequence":"additional","affiliation":[{"name":"Cleveland Clinic  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Federico","sequence":"additional","affiliation":[{"name":"Centro Oncologico Modenese  Policlinico Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gisselbrecht","sequence":"additional","affiliation":[{"name":"Saint Louis Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schwartz","sequence":"additional","affiliation":[{"name":"MS Biostatistics, LLC  Clermont Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Bellm","sequence":"additional","affiliation":[{"name":"MedNet Solutions  Minnetonka Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Acosta","sequence":"additional","affiliation":[{"name":"Spectrum Pharmaceuticals, Inc  Irvine California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjana H.","family":"Advani","sequence":"additional","affiliation":[{"name":"Stanford University Medical Center  Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Feldman","sequence":"additional","affiliation":[{"name":"Hackensack University Medical Center  Hackensack New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Jo","family":"Lechowicz","sequence":"additional","affiliation":[{"name":"Emory University  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali M.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Chicago  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6027-3359","authenticated-orcid":false,"given":"Frederick","family":"Lansigan","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard University School of Medicine  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Tulpule","sequence":"additional","affiliation":[{"name":"University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Craig","sequence":"additional","affiliation":[{"name":"West Virginia University  Morgantown West Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Greer","sequence":"additional","affiliation":[{"name":"Vanderbilt University  Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad S.","family":"Kahl","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph W.","family":"Leach","sequence":"additional","affiliation":[{"name":"Virginia Piper Cancer Institute  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Morganstein","sequence":"additional","affiliation":[{"name":"Overlook Medical Center  Summit New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Casulo","sequence":"additional","affiliation":[{"name":"University of Rochester  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei R.","family":"Shustov","sequence":"additional","affiliation":[{"name":"University of Washington Medical Center  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the COMPLETE 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