{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:39:47Z","timestamp":1786977587823,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008359","name":"Maag Lever Darm Stichting","doi-asserted-by":"publisher","award":["FP14-04"],"award-info":[{"award-number":["FP14-04"]}],"id":[{"id":"10.13039\/501100008359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,3,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hodgkin lymphoma (HL) survivors treated with abdominal radiotherapy and\/or alkylating chemotherapy have an increased risk of colorectal cancer (CRC). This study was aimed at evaluating the prevalence of colorectal neoplasia in HL survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter cohort study assessed the diagnostic yield of advanced colorectal neoplasia detected by a first surveillance colonoscopy among HL survivors treated with abdominal radiotherapy and\/or procarbazine. Advanced colorectal neoplasia included advanced adenomas (high\u2010grade dysplasia, \u226525% villous component, or \u226510\u2010mm diameter), advanced serrated lesions (dysplasia or \u226510\u2010mm diameter), and CRC. The results were compared with those for a Dutch general population cohort that underwent a primary screening colonoscopy (1426 asymptomatic individuals 50\u201075 years old). This study demonstrated the results of a predefined interim analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A colonoscopy was performed in 101 HL survivors, who were significantly younger (median, 51 years; interquartile range [IQR], 45\u201057 years) than the general population controls (median, 60 years; IQR, 55\u201065 years;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). The prevalence of advanced neoplasia was higher in HL survivors than controls (25 of 101 [25%] vs 171 of 1426 [12%];\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Advanced adenomas were detected in 14 of 101 HL survivors (14%) and in 124 of 1426 controls (9%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.08). The prevalence of advanced serrated lesions was higher in HL survivors than controls (12 of 101 [12%] vs 55 of 1426 [4%];\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Serrated polyposis syndrome was present in 6% of HL survivors and absent in controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HL survivors treated with abdominal radiotherapy and\/or procarbazine have a high prevalence of advanced colorectal neoplasia. The implementation of a colonoscopy surveillance program should be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31903","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T11:07:56Z","timestamp":1545131276000},"page":"990-999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["High prevalence of advanced colorectal neoplasia and serrated polyposis syndrome in Hodgkin lymphoma survivors"],"prefix":"10.1002","volume":"125","author":[{"given":"Lisanne S.","family":"Rigter","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Netherlands Cancer Institute Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon C. 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