{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:00:16Z","timestamp":1792144816211,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"GlaxoSmithKline Biologicals SA"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2019,4,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The adjuvanted recombinant zoster vaccine (RZV) has demonstrated &gt;90% efficacy against herpes zoster in adults \u226550 years of age and 68% efficacy in autologous hematopoietic stem cell transplant recipients \u226518 years of age. We report the immunogenicity and safety of RZV administered to patients with solid tumors (STs) before or at the start of a chemotherapy cycle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      In this phase 2\/3 observer\u2010blind, multicenter study (NCT01798056), patients with STs who were \u226518 years of age were randomized (1:1) to receive 2 doses of RZV or placebo 1\u20102 months apart and stratified (4:1) according to the timing of the first dose with respect to the start of a chemotherapy cycle (first vaccination 8\u201030 days before the start or at the start [\u00b11 day] of a chemotherapy cycle). Anti\u2010glycoprotein E (gE) antibody concentrations, gE\u2010specific CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cell frequencies, and vaccine response rates (VRRs) were assessed 1 month after dose 1 and 1 and 12 months after dose 2. Reactogenicity and safety were assessed in the total vaccinated cohort through 12 months after dose 2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 232 participants in the total vaccinated cohort, 185 participants in the according\u2010to\u2010protocol cohort for humoral immunogenicity, and 58 participants in the according\u2010to\u2010protocol cohort for cell\u2010mediated immunogenicity. Postvaccination anti\u2010gE antibody concentrations, gE\u2010specific CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cell frequencies and VRRs were higher in RZV recipients than in placebo recipients. Solicited adverse events (AEs) were more frequent among RZV recipients than placebo recipients. Incidence of unsolicited AEs, serious AEs, fatalities, and potential immune\u2010mediated diseases were similar between RZV and placebo recipients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RZV was immunogenic in patients with STs receiving immunosuppressive chemotherapies. Humoral and cell\u2010mediated immune responses persisted 1 year after vaccination. No safety concerns were identified.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.31909","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T16:16:11Z","timestamp":1549037771000},"page":"1301-1312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Immunogenicity and safety of the adjuvanted recombinant zoster vaccine in patients with solid tumors, vaccinated before or during chemotherapy: A randomized trial"],"prefix":"10.1002","volume":"125","author":[{"given":"Peter","family":"Vink","sequence":"first","affiliation":[{"name":"GSK Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Delgado Mingorance","sequence":"additional","affiliation":[{"name":"Hospital Infanta Cristina Badajoz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Maximiano Alonso","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belen","family":"Rubio\u2010Viqueira","sequence":"additional","affiliation":[{"name":"Hospital Universitario Quiron Madrid Pozuelo de Alarc\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Hae","family":"Jung","sequence":"additional","affiliation":[{"name":"Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Francisco","family":"Rodriguez Moreno","sequence":"additional","affiliation":[{"name":"Centro Integral Oncologico Clara Campal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Grande","sequence":"additional","affiliation":[{"name":"Ramon y Cajal University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Marrupe Gonzalez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Mostoles Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lowndes","sequence":"additional","affiliation":[{"name":"Great Western Hospital Swindon United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Puente","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Hospital Cl\u00ednico San Carlos Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut","family":"Kristeleit","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Woolwich United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Farrugia","sequence":"additional","affiliation":[{"name":"Cheltenham General Hospital Gloucestershire United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly A.","family":"McNeil","sequence":"additional","affiliation":[{"name":"Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority Dalhousie University Halifax Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Campora","sequence":"additional","affiliation":[{"name":"GSK Wavre Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Di Paolo","sequence":"additional","affiliation":[{"name":"GSK Rixensart Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El Idrissi","sequence":"additional","affiliation":[{"name":"GSK Rixensart Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Godeaux","sequence":"additional","affiliation":[{"name":"Novadip Biosciences s.a. 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